Evidence map›Paper›PMID 27139250›Full record

ArticleStatistics in medicine2016

A flexible, interpretable framework for assessing sensitivity to unmeasured confounding.

Vincent Dorie, Masataka Harada, Nicole Bohme Carnegie, Jennifer Hill

Abstract read
In one paragraph

Article in Statistics in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Getting to Know Worst-Case Confounders.Observational studies · 2026
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  15. A Semiparametric Approach to Model-Based Sensitivity Analysis in Observational Studies.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2022
    Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vincent DorieHumanities & the Social Sciences, New York University, New York, NY, U.S.A.
Masataka HaradaEconomics, Fukuoka University, Fukuoka, Japan.
Nicole Bohme CarnegieZilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, U.S.A.ORCID 0000-0001-7664-6682
Jennifer HillHumanities & the Social Sciences, New York University, New York, NY, U.S.A.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

When estimating causal effects, unmeasured confounding and model misspecification are both potential sources of bias. We propose a method to simultaneously address both issues in the form of a semi-parametric sensitivity analysis. In particular, our approach incorporates Bayesian Additive Regression Trees into a two-parameter sensitivity analysis strategy that assesses sensitivity of posterior distributions of treatment effects to choices of sensitivity parameters. This results in an easily interpretable framework for testing for the impact of an unmeasured confounder that also limits the number of modeling assumptions. We evaluate our approach in a large-scale simulation setting and with high blood pressure data taken from the Third National Health and Nutrition Examination Survey. The model is implemented as open-source software, integrated into the treatSens package for the R statistical programming language. © 2016 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd.

Indexed as

Bayes TheoremConfounding Factors, EpidemiologicNutrition SurveysBiasHumansBayesian modelingcausal inferencenonparametric regressionsensitivity analysisunmeasured confounding

Identifiers

PMID27139250
PMCPMC5084780

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.