ArticlePsychiatry research2016
Diagnosis and characterization of mania: Quantifying increased energy and activity in the human behavioral pattern monitor.
Article in Psychiatry research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Motor Abnormalities and the Hierarchical Taxonomy of Psychopathology: Incorporating a Psychomotor Perspective Into a Hierarchical Dimensional Symptom Framework.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Quantifying Exploratory Behavior In The Human Behavioral Pattern Monitor Using Automated Video Tracking.Methods in Psychology (Online) · 2025Article
- Circadian rhythm parameters differentiate euthymic, manic and depressive mood states in bipolar disorders - an explorative pilot study.International journal of bipolar disorders · 2025Article
- Mood or energy/activity symptoms in bipolar mania: which are the most informative?Trends in psychiatry and psychotherapy · 2024Article
- Evidence-Informed Approach to De-Prescribing of Atypical Antipsychotics (AAP) in the Management of Behavioral Expressions (BE) in Advanced Neurocognitive Disorders (NCD): Results of a Retrospective Study.Geriatrics (Basel, Switzerland) · 2022Article
- How Does Adding the DSM-5 Criterion Increased Energy/Activity for Mania Change the Bipolar Landscape?Frontiers in psychiatry · 2021Review
- The COMT Val158Met Polymorphism and Exploratory Behavior in Bipolar Mania.Molecular neuropsychiatry · 2018Article
- Changes in energy and motor activity: core symptoms of bipolar mania and depression?Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Increased energy or activity is now an essential feature of the mania of Bipolar Disorder (BD) according to DSM-5. This study examined whether objective measures of increased energy can differentiate manic BD individuals and provide greater diagnostic accuracy compared to rating scales, extending the work of previous studies with smaller samples. We also tested the relationship between objective measures of energy and rating scales. 50 hospitalized manic BD patients were compared to healthy subjects (HCS, n=39) in the human Behavioral Pattern Monitor (hBPM) which quantifies motor activity and goal-directed behavior in an environment containing novel stimuli. Archival hBPM data from 17 schizophrenia patients were used in sensitivity and specificity analyses. Manic BD patients exhibited higher motor activity than HCS and higher novel object interactions. hBPM activity measures were not correlated with observer-rated symptoms, and hBPM activity was more sensitive in accurately classifying hospitalized BD subjects than observer ratings. Although the findings can only be generalized to inpatient populations, they suggest that increased energy, particularly specific and goal-directed exploration, is a distinguishing feature of BD mania and is best quantified by objective measures of motor activity. A better understanding is needed of the biological underpinnings of this cardinal feature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.