ReviewEuropean journal of pediatrics2016
The pathophysiology of monosymptomatic nocturnal enuresis with special emphasis on the circadian rhythm of renal physiology.
Review in European journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 74 citations in OpenAlex.
- Enuresis, ADHD and BDNF: A Narrative Review of the Hypothesized Interconnections and Potential Triplet Relationship.Brain sciences · 2026Review
- Association between joint hypermobility and primary nocturnal enuresis: a cross-sectional study in children aged 6-13 years.BMC pediatrics · 2025Article
- Inverse association between dietary flavonoid intake and nocturia in middle-aged and older adults from NHANES 2007-2010.Scientific reports · 2025Article
- Parental perception of nocturnal enuresis in a local region of Saudi Arabia.Journal of medicine and life · 2024Article
- Glucocorticoids coordinate the bladder peripheral clock and diurnal micturition pattern in mice.Communications biology · 2023Article
- Urine metabolic phenotyping in children with nocturnal enuresis and comorbid neurobehavioral disorders.Scientific reports · 2021Article
- Pathogenesis and brain functional imaging in nocturnal enuresis: A review.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Could Evening Dietary Protein Intake Play a Role in Nocturnal Polyuria?Journal of clinical medicine · 2020Article
- Exploration of the Optimal Desmopressin Treatment in Children With Monosymptomatic Nocturnal Enuresis: Evidence From a Chinese Cohort.Frontiers in pediatrics · 2020Article
- The effect of a multidisciplinary weight loss program on renal circadian rhythm in obese adolescents.European journal of pediatrics · 2019Article
- Is copeptin a reliable biomarker of primary monosymptomatic nocturnal enuresis?Central-European journal of immunology · 2019Article
- Bladder and bowel dysfunctions in 1748 children referred to pelvic physiotherapy: clinical characteristics and locomotor problems in primary, secondary, and tertiary healthcare settings.European journal of pediatrics · 2017Article
- Recent advances in managing and understanding enuresis.F1000Research · 2017Review
- Comparative response of Desmopressin versus Combination Therapy (Desmopressin + Oxybutynin) in Children with Nocturnal Enuresis.Pakistan journal of medical sciencesArticle
- Nocturia, nocturnal polyuria, and nocturnal enuresis in adults: What we know and what we do not know.Tzu chi medical journalReview
- Brazilian consensus in enuresis-recomendations for clinical practice.International braz j urol : official journal of the Brazilian Society of UrologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledNocturnal polyuria in monosymptomatic nocturnal enuresis (MNE) has so far mainly been attributed to a disturbed circadian rhythm of renal water handling. Low vasopressin levels overnight correlate with absent maximal concentrating activity, resulting in an increased nocturnal diuresis with low urinary osmolality. Therefore, treatment with desmopressin is a rational choice. Unfortunately, 20 to 60 % of children with monosymptomatic enuresis are desmopressin-resistant. There is increasing evidence that other disturbed circadian rhythms might play a role in nocturnal polyuria. This review focuses on renal aspects in the pathophysiology of nocturnal polyuria in MNE, with special emphasis on circadian rhythms. Articles related to renal circadian rhythms and enuresis were searched through the PubMed library with the goal of providing a concise review.
conclusionNocturnal polyuria can only partially be explained by blunted circadian rhythm of vasopressin secretion. Other alterations in the intrinsic renal circadian clock system also seem to be involved, especially in desmopressin-resistant enuresis. WHAT IS KNOWN: • Disturbance in the circadian rhythm of arginine vasopressin secretion is related to nocturnal polyuria in children with enuresis. • Desmopressin is recommended as a treatment for monosymptomatic nocturnal enuresis, working as a vasopressin analogue acting on V2 receptors in the collecting ducts of the kidney. What is New: • Other renal circadian rhythms might play a role in nocturnal polyuria, especially in desmopressin-resistant case.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.