ArticleScientific reports2016
In vivo 3D measurement of moxifloxacin and gatifloxacin distributions in the mouse cornea using multiphoton microscopy.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Structural changes in the crystalline lens as a function of the postmortem interval assessed with two-photon imaging microscopy.Biomedical optics express · 2024Article
- Clinically Compatible Fluorescence Microscopy Based on Moxifloxacin Antibiotic.Advances in experimental medicine and biology · 2021Article
- Ultrasound-assisted gatifloxacin delivery in mouse cornea, in vivo.Scientific reports · 2019Article
- Two-photon microscopy of Paneth cells in the small intestine of live mice.Scientific reports · 2018Article
- Two-photon probes for in vivo multicolor microscopy of the structure and signals of brain cells.Brain structure & function · 2018Review
- Three-photon tissue imaging using moxifloxacin.Scientific reports · 2018Article
- Visualization of laser tattoo removal treatment effects in a mouse model by two-photon microscopy.Biomedical optics express · 2017Article
- Brain tumor delineation enhanced by moxifloxacin-based two-photon/CARS combined microscopy.Biomedical optics express · 2017Article
- Visualization of prostatic nerves by polarization-sensitive optical coherence tomography.Biomedical optics express · 2016Article
- Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Moxifloxacin and gatifloxacin are fourth-generation fluoroquinolone antibiotics used in the clinic to prevent or treat ocular infections. Their pharmacokinetics in the cornea is usually measured from extracted ocular fluids or tissues, and in vivo direct measurement is difficult. In this study multiphoton microscopy (MPM), which is a 3D optical microscopic technique based on multiphoton fluorescence, was applied to the measurement of moxifloxacin and gatifloxacin distribution in the cornea. Intrinsic multiphoton fluorescence properties of moxifloxacin and gatifloxacin were characterized, and their distributions in mouse cornea in vivo were measured by 3D MPM imaging. Both moxifloxacin and gatifloxacin had similar multiphoton spectra, while moxifloxacin had stronger fluorescence than gatifloxacin. MPM imaging of mouse cornea in vivo showed (1) moxifloxacin had good penetration through the superficial corneal epithelium, while gatifloxacin had relatively poor penetration, (2) both ophthalmic solutions had high intracellular distribution. In vivo MPM results were consistent with previous studies. This study demonstrates the feasibility of MPM as a method for in vivo direct measurement of moxifloxacin and gatifloxacin in the cornea.
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