ArticleeLife2016
An extrasynaptic GABAergic signal modulates a pattern of forward movement in Caenorhabditis elegans.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 71 citations in OpenAlex.
- A framework for analyzing globaleLife · 2026Article
- Neural sequences underlying directed turning in Caenorhabditis elegans.Nature neuroscience · 2026Article
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- Excitatory GABA receptors shape locomotor circuit organization in C. elegans.Scientific reports · 2026Article
- Decomposed Linear Dynamical Systems (dLDS) models reveal instantaneous, context-dependent dynamic connectivity in C. elegans.Communications biology · 2025Article
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- Neuronal sensorimotor integration guiding salt concentration navigation inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Semantic representation of neural circuit knowledge in Caenorhabditis elegans.Brain informatics · 2023Article
- Semantic Representation of Neural Circuit Knowledge inbioRxiv : the preprint server for biology · 2023Article
- A proprioceptive feedback circuit drivesProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Extrasynaptic signaling enables an asymmetric juvenile motor circuit to produce symmetric undulation.Current biology : CB · 2022Article
- Composition of Nonextractable Polyphenols from Sweet Cherry Pomace Determined by DART-Orbitrap-HRMS and TheirJournal of agricultural and food chemistry · 2022Article
- A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior.eLife · 2021Article
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- The Prop1-like homeobox geneeLife · 2021Article
- Optical volumetric projection with large NA objectives for fast high-resolution 3D imaging of neural signals.Biomedical optics express · 2020Article
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- Gain control in the sensorimotor system.Current opinion in physiology · 2019Article
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Corrections and comments
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
Abstract
As a common neurotransmitter in the nervous system, γ-aminobutyric acid (GABA) modulates locomotory patterns in both vertebrates and invertebrates. However, the signaling mechanisms underlying the behavioral effects of GABAergic modulation are not completely understood. Here, we demonstrate that a GABAergic signal in C. elegans modulates the amplitude of undulatory head bending through extrasynaptic neurotransmission and conserved metabotropic receptors. We show that the GABAergic RME head motor neurons generate undulatory activity patterns that correlate with head bending and the activity of RME causally links with head bending amplitude. The undulatory activity of RME is regulated by a pair of cholinergic head motor neurons SMD, which facilitate head bending, and inhibits SMD to limit head bending. The extrasynaptic neurotransmission between SMD and RME provides a gain control system to set head bending amplitude to a value correlated with optimal efficiency of forward movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.