ArticleThe American journal of psychiatry2016
Concurrent and Sustained Cumulative Effects of Adolescent Marijuana Use on Subclinical Psychotic Symptoms.
Article in The American journal of psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Unhealthy behaviors associated with mental health disorders: a systematic comparative review of diet quality, sedentary behavior, and cannabis and tobacco use.Frontiers in public health · 2023Pooled it
- The Behavioral Sequelae of Cannabis Use in Healthy People: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- ΔBiological psychiatry. Cognitive neuroscience and neuroimaging · 2026Trial
- Investigating medical cannabis for adolescents with Tourette syndrome: tread carefully.BJPsych open · 2026Article
- Longitudinal analysis of the ABCD® study.Developmental cognitive neuroscience · 2025Review
- Chronic exposure to inhaled vaporized cannabis high in ΔFrontiers in pharmacology · 2024Article
- Using Task-fMRI to Explore the Relationship Between Lifetime Cannabis Use and Cognitive Control in Individuals With First-Episode Schizophrenia.Schizophrenia bulletin open · 2024Article
- Cannabis and tobacco use among adolescents aged 12-17 years from 16 low- and middle-income countries.Journal of global health · 2023Article
- Daily ΔBiological psychiatry global open science · 2023Article
- Recreational Marijuana Use, Adolescent Cognitive Development, and Schizophrenia Susceptibility.Biological psychiatry global open science · 2023Article
- State Cannabis Legalization and Psychosis-Related Health Care Utilization.JAMA network open · 2023Article
- Psychotic symptoms and its associated factors relating to psychoactive substance use among the youth population in Northwest Ethiopia.Frontiers in psychiatry · 2023Article
- Affective Dysregulation Precedes Emergence of Psychosis-Like Experiences in a Community Sample of Young Adults.Schizophrenia bulletin · 2022Article
- Cannabinoids, reward processing, and psychosis.Psychopharmacology · 2022Review
- Measurement invariance between online and paper-and-pencil formats of the Launay-Slade Hallucinations scale-extended (LSHS-E) in the Chilean population: Invariance between LSHS-E formats.Current psychology (New Brunswick, N.J.) · 2022Article
- Perceived risk of harm from monthly cannabis use among US adolescents: National Survey on drug Use and Health, 2017.Preventive medicine reports · 2021Article
- Schizophrenia and the Environment: Within-Person Analyses May be Required to Yield Evidence of Unconfounded and Causal Association-The Example of Cannabis and Psychosis.Schizophrenia bulletin · 2021Article
- Cannabis, schizophrenia genetic risk, and psychotic experiences: a cross-sectional study of 109,308 participants from the UK Biobank.Translational psychiatry · 2021Article
- Attenuated Psychotic Symptoms in Adolescents With Chronic Cannabis and MDMA Use.Frontiers in psychiatry · 2021Article
- Risk factors for the onset of dependence and chronic psychosis due to cannabis use: Survey of patients with cannabis-related psychiatric disorders.Neuropsychopharmacology reports · 2020Article
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Funding
Abstract
objectiveAdolescents who regularly use marijuana may be at heightened risk of developing subclinical and clinical psychotic symptoms. However, this association could be explained by reverse causation or other factors. To address these limitations, the current study examined whether adolescents who engage in regular marijuana use exhibit a systematic increase in subclinical psychotic symptoms that persists during periods of sustained abstinence.
methodThe sample comprised 1,009 boys who were recruited in 1st and 7th grades. Self-reported frequency of marijuana use, subclinical psychotic symptoms, and several time-varying confounds (e.g., other substance use, internalizing/externalizing problems) were recorded annually from age 13 to 18. Fixed-effects (within-individual change) models examined whether adolescents exhibited an increase in their subclinical psychotic symptoms as a function of their recent and/or cumulative history of regular marijuana use and whether these effects were sustained following abstinence. Models controlled for all time-stable factors (default) and several time-varying covariates as potential confounds.
resultsFor each year adolescent boys engaged in regular marijuana use, their expected level of subsequent subclinical psychotic symptoms rose by 21% and their expected odds of experiencing subsequent subclinical paranoia or hallucinations rose by 133% and 92%, respectively. The effect of prior regular marijuana use on subsequent subclinical psychotic symptoms persisted even when adolescents stopped using marijuana for a year. These effects were after controlling for all time-stable and several time-varying confounds. No support was found for reverse causation.
conclusionsThese results suggest that regular marijuana use may significantly increase the risk that an adolescent will experience persistent subclinical psychotic symptoms.
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