ArticleInfection2016
Cranial imaging findings in neurobrucellosis: results of Istanbul-3 study.
Article in Infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Frequency of Human Brucellosis Complications in West Asia: A Systematic Review and Meta-Analysis.MicrobiologyOpen · 2026Pooled it
- Pooled it
- Isolated oculomotor nerve palsy as the sole presenting feature of neurobrucellosis: a case report.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- The impact of previous brucellosis treatment on the clinical course of neurobrucellosis: a multicentre retrospective study.BMC infectious diseases · 2026Article
- RETRACTED: Brucella melitensis infection with osteoarticular involvement: First reported cases in Colombia. https://doi.org/10.7705/biomedica.8614Biomedica : revista del Instituto Nacional de Salud · 2026Article
- An unusual case of neurobrucellosis with intracranial hypertension and bilateral abducens nerve palsy.BMC infectious diseases · 2026Article
- Neurobrucellosis: An Uncommon but Important Cause of Sensorineural Hearing Loss: a case report.Journal of otology · 2026Article
- Neurobrucellosis in an 11-year-old child: A rare case report of brain microabscesses from an endemic region.The Journal of international medical research · 2026Article
- A rare case report of neuro-brucellosis with concurrence of depression, visual impairment, bilateral sensorineural hearing loss, and paraplegia.PLoS neglected tropical diseases · 2025Article
- Neurobrucellosis presenting as acute stroke with brain abscesses: a case report.American journal of neurodegenerative disease · 2025Article
- Neurobrucellosis and Multiple Sclerosis: Cause, Confounder, or Coincidence?Revista da Sociedade Brasileira de Medicina Tropical · 2025Article
- Neurobrucellosis Presenting as a Conglomerate Space-Occupying Lesion.Annals of Indian Academy of Neurology · 2025Article
- Seronegative brucella meningitis diagnosed by CSF PCR: report on seven cases.BMC infectious diseases · 2024Article
- Pediatric neurobrucellosis and atypical Guillain-Barré syndrome: an intriguing case unveiled.Journal of medicine and life · 2024Article
- Neurobrucellosis: laboratory features, clinical characteristics, antibiotic treatment, and clinical outcomes of 21 patients.BMC infectious diseases · 2024Article
- A comparison of clinical features between neurobrucellosis and tuberculous meningitis.BMC neurology · 2024Article
- Article
- Brucellosis infection complicated with myelitis: a case report and literature review.Frontiers in cellular and infection microbiology · 2024Review
- Neurobrucellosis: report of 54 cases.Tropical medicine and health · 2022Article
- Ocular Lesions in Brucella Infection: A Review of the Literature.Infection and drug resistance · 2022Review
Corrections and comments
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Authors and funding
47 authors at 20 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNeuroimaging abnormalities in central nervous system (CNS) brucellosis are not well documented. The purpose of this study was to evaluate the prevalence of imaging abnormalities in neurobrucellosis and to identify factors associated with leptomeningeal and basal enhancement, which frequently results in unfavorable outcomes.
methodsIstanbul-3 study evaluated 263 adult patients with CNS brucellosis from 26 referral centers and reviewed their 242 magnetic resonance imaging (MRI) and 226 computerized tomography (CT) scans of the brain.
resultsA normal CT or MRI scan was seen in 143 of 263 patients (54.3 %). Abnormal imaging findings were grouped into the following four categories: (a) inflammatory findings: leptomeningeal involvements (44), basal meningeal enhancements (30), cranial nerve involvements (14), spinal nerve roots enhancement (8), brain abscesses (7), granulomas (6), and arachnoiditis (4). (b) White-matter involvement: white-matter involvement (32) with or without demyelinating lesions (7). (c) Vascular involvement: vascular involvement (42) mostly with chronic cerebral ischemic changes (37). (d) Hydrocephalus/cerebral edema: hydrocephalus (20) and brain edema (40). On multivariate logistic regression analysis duration of symptoms since the onset (OR 1.007; 95 % CI 1-28, p = 0.01), polyneuropathy and radiculopathy (OR 5.4; 95 % CI 1.002-1.013, p = 0.044), cerebrospinal fluid (CSF)/serum glucose rate (OR 0.001; 95 % CI 000-0.067, p = 0.001), and CSF protein (OR 2.5; 95 % CI 2.3-2.7, p = 0.0001) were associated with diffuse inflammation.
conclusionsIn this study, 45 % of neurobrucellosis patients had abnormal neuroimaging findings. The duration of symptoms, polyneuropathy and radiculopathy, high CSF protein level, and low CSF/serum glucose rate were associated with inflammatory findings on imaging analyses.
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