Evidence map›Paper›PMID 27138236›Full record

Trial reportMedical science monitor : international medical journal of experimental and clinical research2016

Levosimendan Versus Dobutamine in Myocardial Injury Patients with Septic Shock: A Randomized Controlled Trial.

Jianb-biao Meng, Ma-hong Hu, Zhi-zhen Lai, Chun-lian Ji, Xiu-juan Xu, Geng Zhang, Shuyuan Tian

Open access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 8 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 8 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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  20. [Effect of vasoactive agents on the prognosis of children in the third stage of hand-foot-mouth disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jianb-biao MengDepartment of Intensive Care Unit, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China (mainland).
Ma-hong HuDepartment of Intensive Care Unit, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China (mainland).
Zhi-zhen LaiDepartment of Intensive Care Unit, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China (mainland).
Chun-lian JiDepartment of Intensive Care Unit, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China (mainland).
Xiu-juan XuDepartment of Intensive Care Unit, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China (mainland).
Geng ZhangDepartment of Intensive Care Unit, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China (mainland).
Shuyuan TianDepartment of Ultrasonography, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China (mainland).
Tongde Hospital of Zhejiang Province · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND We aimed to investigate the effect of levosimendan on biomarkers of myocardial injury and systemic hemodynamics in patients with septic shock. MATERIAL AND METHODS After achieving normovolemia and a mean arterial pressure of at least 65 mmHg, 38 septic shock patients with low cardiac output (left ventricular ejective fraction), LEVF £45%) were randomly divided into two groups: levosimendan dobutamine. Patients in the levosimendan and dobutamine groups were maintained with intravenous infusion of levosimendan (0.2 μg/kg/minute) and dobutamine (5 μg/kg/minute) for 24 hours respectively. During treatment we monitored hemodynamics and LVEF, and measured levels of heart-type fatty acid binding protein (HFABP), troponin I (TNI), and brain natriuretic peptide(BNP). In addition, the length of mechanical ventilation, intensive care unit (ICU) stay, hospital stay, and 28-day mortality were compared between the two groups. RESULTS The levosimendan group and the dobutamine group were well matched with respect to age (years, 55.4 ± 1 7.5 versus 50.2 ± 13.6) and gender (males, 68.4% versus 57.9%). Levosimendan-treated patients had higher stroke volume index (SVI), cardiac index (CI), LVEF, and left ventricular stroke work index (LVSWI), and lower extravascular lung water index (EVLWI) compared to dobutamine-treated patients (p<0.05). HFABP, TNI, and BNP in the levosimendan group were less than in the dobutamine group (p<0.05). There was no difference in the mechanical ventilation time, length of stay in ICU and hospital, and 28-day mortality between the two groups. CONCLUSIONS Compared with dobutamine, levosimendan reduces biomarkers of myocardial injury and improves systemic hemodynamics in patients with septic shock. However, it does not reduce the days on mechanical ventilation, length of stay in ICU and hospital, or 28-day mortality.

Indexed as

BiomarkersDemographyDobutamineFatty Acid-Binding ProteinsFemaleHemodynamicsHumansHydrazonesLactic AcidMaleMiddle AgedMultivariate AnalysisMyocardiumNatriuretic Peptide, BrainPyridazinesRegression AnalysisBiomarkersDobutamineFatty Acid-Binding ProteinsHydrazonesLactic AcidNatriuretic Peptide, BrainPyridazinesSimendanTroponin I

Identifiers

PMID27138236
PMCPMC4861009
OpenAlexW2346149673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.