SynthesisJournal of psychiatric practice2016
Comorbid Anxiety and Depressive Symptoms in Children and Adolescents: A Systematic Review and Analysis.
Synthesis in Journal of psychiatric practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
91 citing papers in PubMed, 6 syntheses or guidelines pooled it, 194 citations in OpenAlex.
- Genetics, epigenetics, and neurobiology of childhood-onset depression: an umbrella review.Molecular psychiatry · 2024Pooled it
- Exercise intervention and improvement of negative emotions in children: a meta-analysis.BMC pediatrics · 2023Pooled it
- Benefits and harms of interventions to improve anxiety, depression, and other mental health outcomes for autistic people: A systematic review and network meta-analysis of randomised controlled trials.Autism : the international journal of research and practice · 2023Pooled it
- A meta-analysis of emotional regulation outcomes in psychological interventions for youth with depression and anxiety.Nature human behaviour · 2021Pooled it
- Co-morbidity between mood and anxiety disorders: A systematic review and meta-analysis.Depression and anxiety · 2021Pooled it
- Prospective associations between peer functioning and social anxiety in adolescents: A systematic review and meta-analysis.Journal of affective disorders · 2021Pooled it
- Executive Functioning in Pediatric Anxiety and Its Relationship to Selective Serotonin Reuptake Inhibitor Treatment Response: A Double-Blind, Placebo-Controlled Trial.Journal of child and adolescent psychopharmacology · 2022Trial
- Randomized Clinical Trial of an Internet-Based Adolescent Depression Prevention Intervention in Primary Care: Internalizing Symptom Outcomes.International journal of environmental research and public health · 2020Trial
- Randomized control trial testing the effectiveness of implemented depression prevention in high-risk adolescents.BMC medicine · 2020Trial
- Anxious depression as a clinically relevant subtype of pediatric major depressive disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2019Trial
- Prevalence, conceptual distinctiveness, and cross-sectional correlates of climate worry in Canadian adolescents.Child and adolescent mental health · 2026Article
- Social Anxiety and Depression in Portuguese and Spanish Adolescents: The Moderating Role of Emotional Intelligence.Child psychiatry and human development · 2026Article
- Changes in resting-state functional connectivity between large-scale brain networks after an intensive arts intervention for adolescents with depression.Translational psychiatry · 2026Article
- Sex-specific neurodevelopmental pathways to depressive symptoms.Molecular psychiatry · 2026Article
- Multisystemic Resilience and Anxious-Depressed Symptoms in Black Youth Exposed to Maternal Syndemics: A Mixed-Method Study.Child psychiatry and human development · 2026Article
- The effectiveness of an adapted modular CBT training for youth with depressive symptoms: a study protocol for an n-of-1 trial.BMC psychology · 2026Article
- The mediating role of anxiety in the association between childhood trauma and suicidal ideation in depression.BMC psychiatry · 2026Article
- The association between academic self-esteem and college students' positive psychological qualities: the mediating role of general self-efficacy.Frontiers in psychology · 2026Article
- Association between COVID-19 diagnosis and severe mental health symptoms in adolescents in southern Brazil.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2026Article
- Prevalence and correlates of probable anxiety and depression among young people: A subnational cross-sectional study in Ghana.Global mental health (Cambridge, England) · 2026Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundA large and extensive body of research has examined comorbid anxiety and depression in adults. Children and adolescents also frequently present with comorbid anxiety and depression; however, research and treatment require unique environmental and neurodevelopmental considerations in children. As a result, our understanding of comorbid anxiety and depression in children and adolescents is limited.
objectiveThe goal of this systematic review was to examine the current literature focused on comorbid anxiety and depression in children and adolescents. The review included theoretical conceptualizations as well as diagnostic, neurobiological, prevention, and treatment considerations. In addition, a proposed algorithm for the treatment of comorbid anxiety and depression in children/adolescents is provided.
methodsThis systematic literature review included 3 discrete searches in Ovid SP Medline, PsycInfo, and PubMed.
resultsThe review included and synthesized 115 articles published between 1987 and 2015. The available evidence suggests that anxiety and depression are common in clinical populations of children and adolescents, and that comorbidity is likely underestimated in children and adolescents. Children and adolescents with comorbid anxiety and depression have unique presentations, greater symptom severity, and treatment resistance compared with those who have either disease in isolation. A dimensional approach may be necessary for the future development of diagnostic strategies and treatments for this population. Nascent neuroimaging work suggests that anxiety and depression each represents a distinct neurobiological phenotype.
conclusionsThe literature that is currently available suggests that comorbid anxiety and depression is a common presentation in children and adolescents. This diagnostic picture underscores the importance of comprehensive dimensional assessments and multimodal evidence-based approaches given the high disease severity. Future research on the neurobiology and the treatment of these common clinical conditions is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.