Evidence map›Paper›PMID 27138013›Full record

ArticlePloS one2016

StreptoBase: An Oral Streptococcus mitis Group Genomic Resource and Analysis Platform.

Wenning Zheng, Tze King Tan, Ian C Paterson, Naresh V R Mutha, Cheuk Chuen Siow, Shi Yang Tan, Lesley A Old, Nicholas S Jakubovics, Siew Woh Choo

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. The First Case ofMedicina (Kaunas, Lithuania) · 2024
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. A Septicemic Child due to a Novel Streptococcal Species,Case reports in infectious diseases · 2025
    Article
  7. Article
  8. A novel LAMP-based assay for the identification ofJournal of clinical microbiology · 2024
    Article
  9. Article
  10. Article
  11. Evaluation of ImmulexHeliyon · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. BMJ case reports · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Wenning ZhengGenome Informatics Research Laboratory, High Impact Research Building (HIR) Building, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Tze King TanGenome Informatics Research Laboratory, High Impact Research Building (HIR) Building, University of Malaya, 50603 Kuala Lumpur, Malaysia.ORCID 0000-0003-1623-615X
Ian C PatersonDepartment of Oral Biology and Biomedical Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Naresh V R MuthaGenome Informatics Research Laboratory, High Impact Research Building (HIR) Building, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Cheuk Chuen SiowGenome Informatics Research Laboratory, High Impact Research Building (HIR) Building, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Shi Yang TanGenome Informatics Research Laboratory, High Impact Research Building (HIR) Building, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Lesley A OldCenter for Oral Health Research, School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, United Kingdom.
Nicholas S JakubovicsCenter for Oral Health Research, School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, United Kingdom.
Siew Woh ChooGenome Informatics Research Laboratory, High Impact Research Building (HIR) Building, University of Malaya, 50603 Kuala Lumpur, Malaysia.
University of Malaya · MYNewcastle Dental Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The oral streptococci are spherical Gram-positive bacteria categorized under the phylum Firmicutes which are among the most common causative agents of bacterial infective endocarditis (IE) and are also important agents in septicaemia in neutropenic patients. The Streptococcus mitis group is comprised of 13 species including some of the most common human oral colonizers such as S. mitis, S. oralis, S. sanguinis and S. gordonii as well as species such as S. tigurinus, S. oligofermentans and S. australis that have only recently been classified and are poorly understood at present. We present StreptoBase, which provides a specialized free resource focusing on the genomic analyses of oral species from the mitis group. It currently hosts 104 S. mitis group genomes including 27 novel mitis group strains that we sequenced using the high throughput Illumina HiSeq technology platform, and provides a comprehensive set of genome sequences for analyses, particularly comparative analyses and visualization of both cross-species and cross-strain characteristics of S. mitis group bacteria. StreptoBase incorporates sophisticated in-house designed bioinformatics web tools such as Pairwise Genome Comparison (PGC) tool and Pathogenomic Profiling Tool (PathoProT), which facilitate comparative pathogenomics analysis of Streptococcus strains. Examples are provided to demonstrate how StreptoBase can be employed to compare genome structure of different S. mitis group bacteria and putative virulence genes profile across multiple streptococcal strains. In conclusion, StreptoBase offers access to a range of streptococci genomic resources as well as analysis tools and will be an invaluable platform to accelerate research in streptococci. Database URL: http://streptococcus.um.edu.my.

Indexed as

Genome, BacterialHumansMouthStreptococcus mitis

Identifiers

PMID27138013
PMCPMC4854451
OpenAlexW2346158912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.