Evidence map›Paper›PMID 27137950›Full record

ArticleEuropean journal of applied physiology2016

Isometric exercise training lowers resting blood pressure and improves local brachial artery flow-mediated dilation equally in men and women.

Mark B Badrov, Shane R Freeman, Mary Ann Zokvic, Philip J Millar, Cheri L McGowan

Registry-linked trialAbstract readComparative StudyControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in European journal of applied physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04467879 (A Pivotal Study To Evaluate The Effectiveness of Isometric Handgrip Therapy In Prehypertensive And Hypertensive Patients), which is not on this map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04467879 naterminatednot on this mapstarted 2020, after this paper: background citation

A Pivotal Study To Evaluate The Effectiveness of Isometric Handgrip Therapy In Prehypertensive And Hypertensive Patients

TypeinterventionalSponsorZona Health, IncRan2020 to 2022Enrolled146ConditionsHypertension, SystolicArmsZona Plus Device, Control Device
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mark B BadrovPhysical Activity and Cardiovascular Research Laboratory, Department of Kinesiology, University of Windsor, 401 Sunset Avenue, Windsor, ON, N9B 3P4, Canada. mbadrov2@uwo.ca.
Shane R FreemanPhysical Activity and Cardiovascular Research Laboratory, Department of Kinesiology, University of Windsor, 401 Sunset Avenue, Windsor, ON, N9B 3P4, Canada.
Mary Ann ZokvicPhysical Activity and Cardiovascular Research Laboratory, Department of Kinesiology, University of Windsor, 401 Sunset Avenue, Windsor, ON, N9B 3P4, Canada.
Philip J MillarClinical Cardiovascular Physiology Laboratory, University Health Network, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON, 6ES 414, Canada.
Cheri L McGowanPhysical Activity and Cardiovascular Research Laboratory, Department of Kinesiology, University of Windsor, 401 Sunset Avenue, Windsor, ON, N9B 3P4, Canada.
University of Windsor · CAToronto General Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIsometric resistance training has repeatedly shown to be an effective exercise modality in lowering resting blood pressure (BP), yet associated mechanisms and sex differences in the response to training remain unclear. Exploration into potential sex differences in the response to isometric resistance training is necessary, as it may allow for more optimal and sex-based exercise prescription, thereby maximizing the efficacy of the training intervention. PURPOSE: Therefore, we investigated, in normotensives, whether sex differences exist in the response to isometric handgrip (IHG) training.

methodsResting BP and endothelium-dependent vasodilation (brachial artery flow-mediated dilation; FMD) were assessed in 11 women (23 ± 4 years) and 9 men (21 ± 2 years) prior to and following 8 weeks of IHG training (four, 2-min unilateral contractions at 30 % of maximal voluntary contraction; 3 days per week).

resultsMain effects of time were observed (all P < 0.05), whereby IHG training reduced systolic BP (Δ 8 ± 6 mmHg), diastolic BP (Δ 2 ± 3 mmHg), mean arterial pressure (Δ 4 ± 3 mmHg), and pulse pressure (Δ 5 ± 7 mmHg), accompanied by increases in absolute (Δ 0.09 ± 0.15 mm) and relative (Δ 2.4 ± 4.1 %) brachial artery FMD; however, no significant sex differences were observed in the magnitude of post-training change in any variable assessed (all P > 0.05).

conclusionIHG training effectively lowers resting BP and improves endothelium-dependent vasodilation in men and women, without significant sex differences in the magnitude of response.

Indexed as

Blood Flow VelocityBlood PressureBrachial ArteryFemaleHand StrengthHumansIsometric ContractionMaleMuscle, SkeletalResistance TrainingSex FactorsTreatment OutcomeYoung AdultEndothelium-dependent vasodilationFlow-mediated dilationHypertensionIsometric exercise trainingResting blood pressureSex differences

Identifiers

PMID27137950
OpenAlexW2347133030

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.