ArticleScientific reports2016
CSN6, a subunit of the COP9 signalosome, is involved in early response to iron deficiency in Oryza sativa.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 25 citations in OpenAlex.
- Novel loci associated with resistance to downy and powdery mildew in grapevine.Frontiers in plant science · 2024Article
- Iron Availability and Homeostasis in Plants: A Review of Responses, Adaptive Mechanisms, and Signaling.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Monoubiquitinated MxIRT1 acts as an iron receptor to determine MxIRT1 vacuole degradation or plasma membrane recycling via endocytosis.Plant signaling & behavior · 2022Article
- Mining of Potential Gene Resources for Breeding Nutritionally Improved Maize.Plants (Basel, Switzerland) · 2022Review
- Inducible Enrichment of Osa-miR1432 Confers Rice Bacterial Blight Resistance through SuppressingInternational journal of molecular sciences · 2021Article
- The Role of Selective Protein Degradation in the Regulation of Iron and Sulfur Homeostasis in Plants.International journal of molecular sciences · 2020Review
- The Molecular Mechanisms Underlying Iron Deficiency Responses in Rice.International journal of molecular sciences · 2019Review
- SNX1-mediated protein recycling: Piecing together the tissue-specific regulation of arabidopsis iron acquisition.Plant signaling & behavior · 2018Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The COP9 signalosome (CSN) plays an important role in proteasome-mediated degradation by regulating CUL1 rubylation of the SCF ligase and is involved in many crucial biological processes. Here, we demonstrate a link between IDEF1 accumulation and the decline in COP9 derubylation activity in response to iron deficiency (-Fe) in rice (Oryza sativa). CSN6 expression is rapidly down-regulated during Fe depletion, contributing to reduced CSN activity, as judged by CSN5 and CUL1 expression, indicating CSN6 is involved in the early stage response of -Fe. In contrast to CSN6, the IDEF1 protein and expression of several iron uptake/utilisation-related genes are increased in response to -Fe. Thus, we constructed CSN6 transgenic sense and antisense lines and found that experimental depletion of CSN6 results in accumulation of the IDEF1 protein and up-regulation of several iron uptake/utilisation-related genes. Furthermore, IDEF1 can be decorated with K48-linked polyubiquitin and degraded via the 26S proteasome. Accumulated IDEF1 in antisense lines led to increased chlorophyll and Fe content in seedlings during -Fe. Collectively, the cellular CSN6 level is decreased during early stages of -Fe to ensure the rapid accumulation of IDEF1, which in turn up-regulates several iron uptake/utilisation-related genes to help overcome -Fe stress in rice.
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