ReviewMammalian genome : official journal of the International Mammalian Genome Society2016
Reciprocal interactions between circadian clocks and aging.
Review in Mammalian genome : official journal of the International Mammalian Genome Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Meta-analysis of transcriptomic datasets identifies genes enriched in the mammalian circadian pacemaker.Nucleic acids research · 2017Pooled it
- Effects of a snack on performance and errors during a simulated 16-h night shift: A randomized, crossover-controlled, pilot study.PloS one · 2021Trial
- Circadian Rhythms and Lung Cancer in the Context of Aging: A Review of Current Evidence.Aging and disease · 2025Review
- Article
- Regulation of Circadian Genes Nr1d1 and Nr1d2 in Sex-Different Manners during Liver Aging.International journal of molecular sciences · 2022Article
- Age and Chronodisruption in Mouse Heart: Effect of the NLRP3 Inflammasome and Melatonin Therapy.International journal of molecular sciences · 2022Article
- Associations between circadian misalignment and telomere length in BD: an actigraphy study.International journal of bipolar disorders · 2022Article
- Aging effects on the diurnal patterns of gut microbial composition in male and female mice.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2021Article
- Sleep in Normal Aging, Homeostatic and Circadian Regulation and Vulnerability to Sleep Deprivation.Brain sciences · 2021Review
- The core circadian component, Bmal1, is maintained in the pineal gland of old killifish brain.iScience · 2021Article
- Aging with rhythmicity. Is it possible? Physical exercise as a pacemaker.Life sciences · 2020Review
- Survival is reduced when endogenous period deviates from 24 h in a non-human primate, supporting the circadian resonance theory.Scientific reports · 2020Article
- Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits.Science advances · 2020Article
- Circadian Photoentrainment in Mice and Humans.Biology · 2020Review
- Aging Affects the Capacity of Photoperiodic Adaptation Downstream from the Central Molecular Clock.Journal of biological rhythms · 2020Article
- Are Owls and Larks Different When it Comes to Aggression? Genetics, Neurobiology, and Behavior.Frontiers in behavioral neuroscience · 2020Article
- Aging and the clock: Perspective from flies to humans.The European journal of neuroscience · 2020Review
- Abnormal Sleep, Circadian Rhythm Disruption, and Delirium in the ICU: Are They Related?Frontiers in neurology · 2020Review
- Advances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD.Frontiers in medicine · 2020Review
- The Development and Decay of the Circadian Clock inClocks & sleep · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Virtually, all biological processes in the body are modulated by an internal circadian clock which optimizes physiological and behavioral performance according to the changing demands of the external 24-h world. This circadian clock undergoes a number of age-related changes, at both the physiological and molecular levels. While these changes have been considered to be part of the normal aging process, there is increasing evidence that disruptions to the circadian system can substantially impact upon aging and these impacts will have clear health implications. Here we review the current data of how both the physiological and core molecular clocks change with age and how feedback from external cues may modulate the aging of the circadian system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.