Evidence map›Paper›PMID 27137742›Full record

ArticleMolecular psychiatry2017

Reexamining associations between mania, depression, anxiety and substance use disorders: results from a prospective national cohort.

M Olfson, R Mojtabai, K R Merikangas, W M Compton, S Wang, B F Grant, C Blanco

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 56 citations in OpenAlex.

  1. Trial
  2. Article
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  4. Global country-level network analysis of mental disorders.Global mental health (Cambridge, England) · 2026
    Article
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  6. Review
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  8. Review
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  15. The clinical characterization of the adult patient with bipolar disorder aimed at personalization of management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022
    Article
  16. Article
  17. Article
  18. A detailed hierarchical model of psychopathology: From individual symptoms up to the general factor of psychopathology.Clinical psychological science : a journal of the Association for Psychological Science · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

M OlfsonDepartment of Psychiatry, College of Physicians and Surgeons of Columbia University, Columbia University Medical Center/New York State Psychiatric Institute, New York, NY, USA.
R MojtabaiDepartment of Mental Health, Bloomberg School of Public Health and Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
K R MerikangasNational Institute of Mental Health, Bethesda, MD, USA.
W M ComptonNational Institute on Drug Abuse, Bethesda, MD, USA.
S WangDepartment of Psychiatry, College of Physicians and Surgeons of Columbia University, Columbia University Medical Center/New York State Psychiatric Institute, New York, NY, USA.
B F GrantNational Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
C BlancoNational Institute on Drug Abuse, Bethesda, MD, USA.
Columbia University Irving Medical Center · USNational Institute on Drug Abuse · USJohns Hopkins University · USNational Institute of Mental Health · USNational Institute on Alcohol Abuse and Alcoholism · US

Funding

National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) - IIIZIAAA000449 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI GRANT, BRIDGET F · 2009 to 2016
$16.5M
Population-Based Epidemiologic ResearchZIAMH002953 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MERIKANGAS, KATHLEEN R · 2016 to 2025
$7.0M
AHRQ HHS U19 HS021112
6 · The paper itself

Abstract

Separate inheritance of mania and depression together with high rates of clinical overlap of mania with anxiety and substance use disorders provide a basis for re-examining the specificity of the prospective association of manic and depression episodes that is a hallmark of bipolar disorder. We analyzed information from 34 653 adults in Waves 1 and 2 of the National Epidemiologic Survey on Alcohol and Related Conditions, a longitudinal nationally representative survey of US adults interviewed 3 years apart. Psychiatric disorders were assessed by a structured interview. We used logistic regression analyses to estimate the strength of associations between Wave 1 manic episodes and Wave 2 depression, anxiety and substance use disorders controlling for background characteristics and lifetime Wave 1 disorders. Corresponding analyses examined associations between Wave 1 major depressive episode with manic episodes and other psychiatric disorders. In multivariable models, Wave 1 manic episodes significantly increased the odds of Wave 2 major depressive episodes (adjusted odds ratio (AOR): 1.7; 95% confidence interval: 1.3-2.2) and any anxiety disorder (AOR: 1.8; 1.4-2.2), although not of substance use disorders (AOR: 1.2; 0.9-1.5). Conversely, Wave 1 major depressive episodes significantly increased risk of Wave 2 manic episodes (AOR: 2.2; 1.7-2.9) and anxiety disorders (AOR: 1.7; 1.5-2.0), although not substance use disorders (AOR: 1.0; 0.9-1.2). Adults with manic episodes have an approximately equivalent relative risk of developing depression episodes and anxiety disorders. Greater research and clinical focus is warranted on connections between manic episodes and anxiety disorders.

Indexed as

AdultAnxietyAnxiety DisordersBipolar DisorderComorbidityDepressionDiagnostic and Statistical Manual of Mental DisordersFemaleHumansLongitudinal StudiesMajor Depressive DisorderMaleMiddle AgedProspective StudiesSubstance-Related Disorders

Identifiers

PMID27137742
OpenAlexW2347007928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.