ArticleScientific reports2016
Charactering the ZFAND3 gene mapped in the sex-determining locus in hybrid tilapia (Oreochromis spp.).
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 16 citations in OpenAlex.
- Noncanonical inheritance of phenotypic information by protein amyloids.Nature cell biology · 2024Article
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- Detecting Local Adaptation between North and South European Atlantic Salmon Populations.Biology · 2022Article
- Fine Mapping Using Whole-Genome Sequencing Confirms Anti-Müllerian Hormone as a Major Gene for Sex Determination in Farmed Nile Tilapia (G3 (Bethesda, Md.) · 2019Article
- Characterization of a male specific region containing a candidate sex determining gene in Atlantic cod.Scientific reports · 2019Article
- SOX2 participates in spermatogenesis of Zhikong scallop Chlamys farreri.Scientific reports · 2019Article
- ddRADseq reveals determinants for temperature-dependent sex reversal in Nile tilapia on LG23.BMC genomics · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Zinc finger AN1-type domain 3 (ZFAND3) is essential for spermatogenesis in mice. However, its function in teleosts remains unclear. In this study, we characterized the ZFAND3 gene (termed as OsZFAND3) in an important food fish, tilapia. The OsZFAND3 cDNA sequence is 1,050 bp in length, containing an ORF of 615 bp, which encodes a putative peptide of 204 amino acid residues. Quantitative real-time PCR revealed that the OsZFAND3 transcripts were exclusively expressed in the testis and ovary. In situ hybridization showed that the high expression of OsZFAND3 transcripts was predominantly localized in the spermatocyte and spermatid. These results suggest that OsZFAND3 is involved in male germ cell maturation. Three single nucleotide polymorphisms (SNPs) were detected in the introns of OsZFAND3. The OsZFAND3 gene was mapped in the sex-determining locus on linkage group 1 (LG1). The three SNPs in the OsZFAND3 gene were strictly associated with sex phenotype, suggesting that the OsZFAND3 gene is tightly linked to the sex-determining locus. Our study provides new insights into the functions of the OsZFAND3 gene in tilapia and a foundation for further detailed analysis of the OsZFAND3 gene in sex determination and differentiation.
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