ArticleMolecules (Basel, Switzerland)2016
Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
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- The Antidiabetic Activity of Wild-Growing and Cultivated Medicinal Plants Used in Romania for Diabetes Mellitus Management: A Phytochemical and Pharmacological Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Optimisation of Phenolic Compound Extraction fromAntioxidants (Basel, Switzerland) · 2025Article
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- Potential use of the Asteraceae family as a cure for diabetes: A review of ethnopharmacology to modern day drug and nutraceuticals developments.Frontiers in pharmacology · 2023Review
- Investigation of Selected Medicinal Plants for Their Anti-Obesity Properties.Turkish journal of pharmaceutical sciences · 2022Article
- Phytochemical and Pharmacological Research inPlants (Basel, Switzerland) · 2022Article
- Vascular Effects of Polyphenols fromPharmaceuticals (Basel, Switzerland) · 2022Article
- Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders.Foods (Basel, Switzerland) · 2022Review
- Trends in diabetes care with special emphasis to medicinal plants: Advancement and treatment.Biocatalysis and agricultural biotechnology · 2021Review
- The therapeutic effects of Agrimonia eupatoria L.Physiological research · 2020Review
- Phenolome of Asian Agrimony Tea (Foods (Basel, Switzerland) · 2020Article
- Biological Effect ofPharmacognosy magazine · 2017Article
- Article
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Authors and funding
9 authors.
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Abstract
Diabetes mellitus (DM) is frequently diagnosed at a time when patients already suffer from several cardiovascular complications. Our previously published data (Molecules 201520 (11): 20538-50) on the anti-oxidative properties of Agrimonia eupatoria L. (AE) and Cynara cardunculus L. (CC) prompted us to extend the available evidence on their possible protective activities on selected DM-related parameters in a streptozotocin-induced DM rat model and in a series of in vitro experiments. Male rats were divided into four groups: control group, untreated diabetic group, AE and CC treated diabetic groups. During a five-week period, changes in blood glucose and body weight were monitored. Then, rats were sacrificed and subjected to the assessment of changes in the reactivity of aortas and measurement of butyrylcholinesterase activity. To complete the panel of experiments, α-glucosidase activity was assessed in vitro. Our results demonstrate that both tested extracts exert similar anti-diabetic activities. However, better anti-oxidant activity of the A. eupatoria extract indicates its higher clinical potential in the prevention and/or adjuvant therapy of developing cardiovascular complications related to DM and diseases associated with oxidative stress.
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