Evidence map›Paper›PMID 27136493›Full record

Trial reportJAMA internal medicine2016

Innovative Self-Regulation Strategies to Reduce Weight Gain in Young Adults: The Study of Novel Approaches to Weight Gain Prevention (SNAP) Randomized Clinical Trial.

Rena R Wing, Deborah F Tate, Mark A Espeland, Cora E Lewis, Jessica Gokee LaRose, Amy A Gorin, Judy Bahnson, Letitia H Perdue, Karen E Hatley, Erica Ferguson and 3 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in JAMA internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01183689 (Study of Novel Approaches for Prevention), which is not on this map. Cited by 71 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01183689 nacompletednot on this map

Study of Novel Approaches for Prevention

TypeinterventionalSponsorWake Forest UniversityRan2010 to 2018Enrolled599ConditionsWeight GainArmsSmall Behavior Changes, Large Behavior Changes
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  9. Life events and stress among young adults in weight gain prevention trial.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023
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  16. A small change approach to prevent long-term weight gain in adults with overweight and obesity: a randomized controlled trial.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2022
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  20. Who loses weight in a weight gain prevention program? A comparison of weight losers and weight maintainers at 3 years.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2021
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Rena R WingAlpert Medical School of Brown University, Miriam Hospital, Providence, Rhode Island.
Deborah F TateUniversity of North Carolina-Chapel Hill, Chapel Hill.
Mark A EspelandWake Forest School of Medicine, Winston Salem, North Carolina.
Cora E LewisDepartment of Medicine, University of Alabama at Birmingham, Birmingham.
Jessica Gokee LaRoseDepartment of Health Behavior and Policy, Virginia Commonwealth University School of Medicine, Richmond.
Amy A GorinDepartment of Psychological Sciences, University of Connecticut, Storr.
Judy BahnsonWake Forest School of Medicine, Winston Salem, North Carolina.
Letitia H PerdueWake Forest School of Medicine, Winston Salem, North Carolina.
Karen E HatleyUniversity of North Carolina-Chapel Hill, Chapel Hill.
Erica FergusonAlpert Medical School of Brown University, Miriam Hospital, Providence, Rhode Island.
Katelyn R GarciaWake Forest School of Medicine, Winston Salem, North Carolina.
Wei LangWake Forest School of Medicine, Winston Salem, North Carolina.
Study of Novel Approaches to Weight Gain Prevention (SNAP) Research Group

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
Carolina Population CenterR24HD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORGAN, SAMUEL PHILIP · 2005 to 2014
$10.0M
Prevention of Weight Gain in Young AdultsU01HL090864 · NHLBI · MIRIAM HOSPITAL · PI WING, RENA R · 2009 to 2014
$5.8M
Study of Novel Approaches to Weight Gain Prevention - Extension (SNAP-E)R01HL127341 · NHLBI · MIRIAM HOSPITAL · PI ESPELAND, MARK ANDREW, TATE, DEBORAH F. · 2015 to 2018
$2.9M
Prevention of Weight Gain in Young AdultsU01HL090875 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ESPELAND, MARK ANDREW · 2009 to 2014
$2.0M
NHLBI NIH HHS R01 HL127341NHLBI NIH HHS U01 HL090864NHLBI NIH HHS U01 HL090875NICHD NIH HHS R24 HD050924NIDDK NIH HHS P30 DK056350
6 · The paper itself

Abstract

importanceWeight gain occurs commonly in young adults and has adverse effects on health.

objectiveTo compare 2 self-regulation interventions vs control in reducing weight gain in young adults over a mean follow-up of 3 years. DESIGN, SETTING, AND

participantsRandomized clinical trial in 2 academic settings of 599 participants aged 18 to 35 years with body mass index (BMI, calculated as weight in kilograms divided by height in meters squared) of 21.0 to 30.0, recruited via mailings and emails from August 2010 to February 2012. Data were analyzed from January 2015 to January 2016.

interventionsParticipants were randomized to control, self-regulation plus small changes, or self-regulation plus large changes. Both interventions focused on frequent self-weighing to cue behavior changes. "Small changes" taught participants to reduce intake and increase activity, both by approximately 100 calories per day. "Large changes" focused on losing 2.3 to 4.5 kg initially to buffer against expected weight gain. MAIN OUTCOMES AND MEASURES: Changes in weight from baseline over mean follow-up of 3 years. Secondary outcomes included proportion gaining at least 0.45 kg from baseline, proportion developing obesity (BMI, ≥30.0), and weight change baseline to 2 years.

resultsAmong the 599 participants (22% men; 27% minority; mean [SD] age, 27.7 [4.4] years; mean [SD] BMI, 25.4 [2.6]), mean (SE) weight changes over a mean follow-up of 3 years were 0.26 (0.22), -0.56 (0.22), and -2.37 (0.22) kg in the control, small-changes, and large-changes groups, respectively (P < .001). Differences among all 3 groups were significant (large changes vs control, P < .001; small changes vs control, P = .02; large changes vs small changes, P < .001). On secondary outcomes, both interventions significantly reduced incidence of obesity relative to control (mean [SE], 8.6% [2.0%], 7.9% [2.0%], and 16.9% [2.7%] in the large-changes, small-changes, and control groups, respectively; P = .02 for large changes vs control and P = .002 for small changes vs control); a smaller percentage of participants in the large-changes group gained 0.45 kg or more (mean [SE], 23.6% [2.8%], 32.5% [3.8%], and 40.8% [4.4%], respectively; P < .001 vs control and P = .02 vs small changes) and weight change from baseline to 2 years was greater in control than in small or large changes (mean [SE], 0.54 [0.33], -0.77 [0.33], and -1.50 [0.34] kg, respectively; P = .02 vs small changes and P < .001 vs large changes). CONCLUSIONS AND RELEVANCE: Self-regulation with large or small changes both reduced weight gain in young adults over 3 years relative to control, but the large-changes intervention was more effective.

trial registrationclinicaltrials.gov Identifier: NCT01183689.

Indexed as

Self-ControlWeight GainAcademic Medical CentersAdolescentAdultBody Mass IndexCase-Control StudiesFemaleFollow-Up StudiesHumansMaleObesityTreatment Outcome

Identifiers

PMID27136493
PMCPMC5461816

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.