ArticleBlood transfusion = Trasfusione del sangue2017
Genotyping approach for non-invasive foetal RHD detection in an admixed population.
Article in Blood transfusion = Trasfusione del sangue, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Prenatal non-invasive foetal RHD genotyping: diagnostic accuracy of a test as a guide for appropriate administration of antenatal anti-D immunoprophylaxis.Blood transfusion = Trasfusione del sangue · 2018Trial
- Clinical Outcomes of Rh(D)-Incompatible Allogeneic Haematopoietic Stem Cell Transplantation: A Single-Centre Retrospective Case Series with a Narrative Literature Review.Journal of blood medicine · 2026Article
- Noninvasive fetal blood group antigen genotyping.Blood transfusion = Trasfusione del sangue · 2025Review
- Terminating Routine Cord Blood RhD Typing of the Newborns to Guide Postnatal Anti-D Immunoglobulin Prophylaxis Based on the Results of Fetal RHD Genotyping.Fetal diagnosis and therapy · 2023Article
- Noninvasive Prenatal Testing in Immunohematology-Clinical, Technical and Ethical Considerations.Journal of clinical medicine · 2022Review
- Algorithm development and diagnostic accuracy testing for non-invasive foetal RHD genotyping: an Indian experience.Blood transfusion = Trasfusione del sangue · 2022Article
- Article
- Establishment of the first platelet-donor registry in Argentina.Blood transfusion = Trasfusione del sangue · 2020Article
- Usefulness of Non-Invasive Fetal RHD Genotyping towards Immunoprophylaxis Optimization.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2018Article
- Transfusion Medicine and Molecular Genetic Methods.International journal of preventive medicine · 2018Review
- A new biosensor for noninvasive determination of fetal RHD status in maternal blood of RhD negative pregnant women.PloS one · 2018Article
- Non-invasive foetal RhD genotyping in admixed populations.Blood transfusion = Trasfusione del sangue · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-invasive foetal RHD genotyping can predict haemolytic disease of the foetus and the newborn in pregnancies with anti-D alloantibodies and also avoid antenatal anti-D prophylaxis in pregnant women carrying an RHD negative foetus. Considering that the Argentine genetic background is the result of generations of intermixing between several ethnic groups, we evaluated the diagnostic performance of a non-invasive foetal RHD determination strategy to guide targeted antenatal RhD immunoprophylaxis. This algorithm is based on the analysis of four regions of the RHD gene in cell-free foetal DNA in maternal plasma and maternal and paternal RHD genotyping. MATERIALS AND
methodsDNA from 298 serologically D negative pregnant women between 19-28 weeks gestation were RHD genotyped. Foetal RHD status was determined by real-time PCR in 296 maternal plasma samples. In particular cases, RHDΨ and RHD-CE-D
resultsOf the 298 maternal samples, 288 were D-/RHD- and 10 D-/RHD+ (2 RHD*DAR; 5 RHD-CE-D DISCUSSION: The protocol used for non-invasive prenatal RHD genotyping proved to be suitable to determine foetal RHD status in our admixed population. The knowledge of the genetic background of the population under study and maternal and paternal molecular analysis can reduce the number of inconclusive results when investigating foetal RHD status.
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