ArticleSmall (Weinheim an der Bergstrasse, Germany)2016
Buoyant Nanoparticles: Implications for Nano-Biointeractions in Cellular Studies.
Article in Small (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Systematic review of potential developmental and reproductive toxicity of microplastics.Toxicological sciences : an official journal of the Society of Toxicology · 2025Pooled it
- Navigating the Landscape of Dry Assembling Ordered Particle Structures: Can Solvents Become Obsolete?Small (Weinheim an der Bergstrasse, Germany) · 2024Review
- Cell-nanoparticle stickiness and dose delivery in a multi-model in silico platform: DosiGUI.Particle and fibre toxicology · 2024Article
- Dispersion and Dosimetric Challenges of Hydrophobic Carbon-Based Nanoparticles in In Vitro Cellular Studies.Nanomaterials (Basel, Switzerland) · 2024Article
- Structural and optical control through anion and cation exchange processes for Sn-halide perovskite nanostructures.Nanoscale · 2024Article
- 3D printer emissions elicit filament-specific and dose-dependent metabolic and genotoxic effects in human airway epithelial cells.Frontiers in public health · 2024Article
- Applying new approach methodologies to assess next-generation tobacco and nicotine products.Frontiers in toxicology · 2024Review
- The State of the Art and Challenges of In Vitro Methods for Human Hazard Assessment of Nanomaterials in the Context of Safe-by-Design.Nanomaterials (Basel, Switzerland) · 2023Review
- Physicochemical and toxicological properties of wood smoke particulate matter as a function of wood species and combustion condition.Journal of hazardous materials · 2023Article
- Investigating nanoplastics toxicity using advanced stem cell-based intestinal and lungFrontiers in toxicology · 2023Review
- The Hitchhiker's Guide to Human Therapeutic Nanoparticle Development.Pharmaceutics · 2022Review
- Understanding nano-engineered particle-cell interactions: biological insights from mathematical models.Nanoscale advances · 2021Review
- Development of Microfluidic, Serum-Free Bronchial Epithelial Cells-on-a-Chip to Facilitate a More RealisticFrontiers in toxicology · 2021Article
- Nanotoxicology and Nanosafety: Safety-By-Design and Testing at a Glance.International journal of environmental research and public health · 2020Review
- Safer-by-design flame-sprayed silicon dioxide nanoparticles: the role of silanol content on ROS generation, surface activity and cytotoxicity.Particle and fibre toxicology · 2019Article
- Article
- Ingested engineered nanomaterials: state of science in nanotoxicity testing and future research needs.Particle and fibre toxicology · 2018Review
- Assessment of reactive oxygen species generated by electronic cigarettes using acellular and cellular approaches.Journal of hazardous materials · 2018Article
- The roles of surface chemistry, dissolution rate, and delivered dose in the cytotoxicity of copper nanoparticles.Nanoscale · 2017Article
- Preparation, characterization, and in vitro dosimetry of dispersed, engineered nanomaterials.Nature protocols · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In the safety and efficacy assessment of novel nanomaterials, the role of nanoparticle (NP) kinetics in in vitro studies is often ignored although it has significant implications in dosimetry, hazard ranking, and nanomedicine efficacy. It is demonstrated here that certain nanoparticles are buoyant due to low effective densities of their formed agglomerates in culture media, which alters particle transport and deposition, dose-response relationships, and underestimates toxicity and bioactivity. To investigate this phenomenon, this study determines the size distribution, effective density, and assesses fate and transport for a test buoyant NP (polypropylene). To enable accurate dose-response assessment, an inverted 96-well cell culture platform is developed in which adherent cells are incubated above the buoyant particle suspension. The effect of buoyancy is assessed by comparing dose-toxicity responses in human macrophages after 24 h incubation in conventional and inverted culture systems. In the conventional culture system, no adverse effects are observed at any NP concentration tested (up to 250 μg mL(-1) ), whereas dose-dependent decreases in viability and increases in reactive oxygen species are observed in the inverted system. This work sheds light on an unknown issue that plays a significant role in vitro hazard screening and proposes a standardized methodology for buoyant NP assessments.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.