ArticleAdvanced biomedical research2016
Distribution of erm genes among Staphylococcus aureus isolates with inducible resistance to clindamycin in Isfahan, Iran.
Article in Advanced biomedical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 50 citations in OpenAlex.
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- New update on molecular diversity of clinical Staphylococcus aureus isolates in Iran: antimicrobial resistance, adhesion and virulence factors, biofilm formation and SCCmec typing.Molecular biology reports · 2022Article
- Mechanisms of Resistance to Macrolide Antibiotics amongAntibiotics (Basel, Switzerland) · 2021Review
- Inducible Clindamycin Resistant Staphylococcus aureus among Patients Attending Tertiary Care Centre: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2021Article
- Comparative Transcriptomic Analysis of Staphylococcus aureus Associated with Periprosthetic Joint Infection under in Vivo and in Vitro Conditions.The Journal of molecular diagnostics : JMD · 2021Article
- Detection, molecular characterization, and antibiogram of multi-drug resistant and methicillin-resistantIranian journal of veterinary research · 2021Article
- Inducible clindamycin resistance andFuture science OA · 2020Article
- Genotypic and Phenotypic Evaluation of Biofilm Production and Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2020Article
- Catchment-scale export of antibiotic resistance genes and bacteria from an agricultural watershed in central Iowa.PloS one · 2020Article
- Analysis of Resistance to Macrolide-Lincosamide-Streptogramin B AmongOsong public health and research perspectives · 2019Article
- Phenotypic and genotypic characterization of macrolide, lincosamide and streptogramin B resistance among clinical isolates of staphylococci in southwest of Iran.BMC research notes · 2018Article
- Understanding the impact of antibiotic therapies on the respiratory tract resistome: a novel pooled-template metagenomic sequencing strategy.Multidisciplinary respiratory medicine · 2018Article
- Phenotypic and genotypic characterization of macrolide resistance amongIranian journal of microbiology · 2017Article
- Prevalence of Genotypes That Determine Resistance of Staphylococci to Macrolides and Lincosamides in Serbia.Frontiers in public health · 2017Article
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8 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe rising frequency of methicillin resistant Staphylococcus aureus (MRSA) has led to an increased use of antibiotics such as macrolide, lincosamide, streptogramin B (MLSB) for the treatment of S. aureus infections. Resistance to MLSB in S. aureus is commonly encoded by erm genes, which can be constitutive MLSB (cMLSB) or inducible MLSB (iMLSB). The purpose of this study was to determine the frequency of cMLSB, iMLSB, and MS phenotypes using D-test and polymerase chain reaction (PCR) methods. MATERIALS AND
methodsA total of 215 isolates of S. aureus were collected from January 2010 to May 2012 from Al-Zahra Hospital in Isfahan. PCR was performed for detection of mecA gene on all isolates using specific primers. The frequency of MLSB-resistant isolates was determined using D-test, and then a multiplex PCR was performed for detection of ermA, ermB, and ermC genes.
resultsAmong 215 S. aureus isolates examined, 82 (40.9%) were MRSA, and iMLSB, cMLSB, and MS resistance phenotypes had a frequency of 9 (4.18%), 58 (26.9%), and 11 (5.1%), respectively. Among nine isolates with iMLSB resistance phenotype, four isolates contained ermC gene, two isolates ermB gene, and one isolate ermA gene. Two isolates did not have any erm gene.
conclusionIn the current study, cMLSB was the most frequent phenotype and ermC was the most common gene in iMLSB resistant phenotypes.
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