A Fatal Case of Acute Myeloid Leukaemia-Methotrexate Related or Primary Autoimmune Disease Related: A Rare Case Report.

Saurabh Agarwal, Nidhi Kaeley, Priyanka Gupta, Vibha Gupta, Rohan Bhatia

Open access · goldAbstract readCase Reports

In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.2field-weighted citation impact, top 42% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Saurabh AgarwalAssistant Professor, Department of Medicine, Himalayan Institute of Medical Sciences , SRHU, Jolly Grant, Dehradun, Uttarakhand, India .

Nidhi KaeleyAssistant Professor, Department of Medicine, Himalayan Institute of Medical Sciences , SRHU, Jolly Grant, Dehradun, Uttarakhand, India .

Priyanka GuptaSenior Resident, Department of Microbiology, Himalayan Institute of Medical Sciences , SRHU, Jolly Grant, Dehradun, Uttarakhand, India .

Vibha GuptaAssistant Professor, Department of Pathology, Himalayan Institute of Medical Sciences , SRHU, Jolly Grant, Dehradun, Uttarakhand, India .

Rohan BhatiaAssistant Professor, Department of Anaesthesia, Himalayan Institute of Medical Sciences , SRHU, Jolly Grant, Dehradun, Uttarakhand, India .

Swami Rama Himalayan University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methotrexate is being used for many years in the treatment of chronic medical disorders e.g. rheumatoid arthritis since 1951. It has been associated with various systemic toxicities and complications including bone marrow suppression and lymphomas. The development of leukaemia in a patient of chronic rheumatoid arthritis is either related with the primary disease or due to the drugs which are used in the treatment like cyclophosphamide. In our present case, a 70-year-old female who was a known case of Rheumatoid Arthritis (RA) and was on methotrexate once a week orally for the past 20 years presented with complaints of loss of appetite, loss of weight and anaemia since 2 months. After thorough examination and investigation, she was diagnosed with acute myeloid leukaemia (AML-M4) with bilateral chest consolidation.

Indexed as

Bone marrow suppressionChest consolidationRheumatoid arthritisSystemic toxicities

Identifiers

PMID27134915

DOI10.7860/JCDR/2016/16516.7359

PMCPMC4843301

OpenAlexW2339548059

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.