Evidence map›Paper›PMID 27134820›Full record

ArticleJournal of obsessive-compulsive and related disorders2016

Probing Implicit Learning in Obsessive-Compulsive Disorder: Moderating Role of Medication on the Weather Prediction Task.

Benjamin Kelmendi, Thomas Adams, Ewgeni Jakubovski, Keith A Hawkins, Vladimir Coric, Christopher Pittenger

Open access · greenAbstract read
In one paragraph

Article in Journal of obsessive-compulsive and related disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Benjamin KelmendiDepartment of Psychiatry, Neuroscience Program Yale University; National Center for Post-Traumatic Stress Disorder VA Connecticut Healthcare System.
Thomas AdamsDepartment of Psychiatry, Neuroscience Program Yale University; National Center for Post-Traumatic Stress Disorder VA Connecticut Healthcare System.
Ewgeni JakubovskiChild Study Center, Neuroscience Program Yale University.
Keith A HawkinsDepartment of Psychiatry, Neuroscience Program Yale University.
Vladimir CoricDepartment of Psychiatry, Neuroscience Program Yale University.
Christopher PittengerDepartment of Psychiatry, Neuroscience Program Yale University; Child Study Center, Neuroscience Program Yale University; Department of Psychology, Neuroscience Program Yale University; Interdepartmental Neuroscience Program Yale University.
Yale University · USVA Connecticut Healthcare System · US

Funding

CREB and the molecular underpinnings of habit learningK08MH081190 · NIMH · YALE UNIVERSITY · PI PITTENGER, CHRISTOPHER JOHN · 2008 to 2012
$897k
NIMH NIH HHS K08 MH081190NIMH NIH HHS L30 MH111037
6 · The paper itself

Abstract

Deficits in implicit learning, a process by which knowledge is acquired accretively through practice independent of conscious awareness, have been implicated in Obsessive-Compulsive Disorder (OCD). The weather-prediction task (WPT) was used to assess implicit learning in 26 unmedicated patients with OCD and 23 healthy controls. An additional analysis compared these two groups with 25 medicated patients with OCD. In the comparison of unmedicated patients with healthy controls there was a subtle but statistically significant group-by-block interaction. Patients with OCD showed slower improvement in performance during the middle phase of learning. In a three-group comparison, there was no main effect of group; in post-hoc tests, medicated patients with OCD differed from unmedicated patients and were not different from healthy controls. Unmedicated patients with OCD have a subtle deficit in implicit learning in the WPT. This may be mitigated by pharmacotherapy, although prospective studies would be required to confirm this conclusion.

Indexed as

implicit learningobsessive-compulsive disorderpharmacotherapyweather prediction task

Identifiers

PMID27134820
PMCPMC4845758
OpenAlexW2335392685

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.