ArticleJournal of intensive care2016
Risk factors for late defecation and its association with the outcomes of critically ill patients: a retrospective observational study.
Article in Journal of intensive care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Improving Constipation in Critical Care Patients: A Single-Centre Prospective Cohort Closed-Loop Clinical Audit.Cureus · 2026Article
- Evolution and economic evaluation of fecal incontinence management in United States intensive care units: from historical containment to automated diversion.Frontiers in medicine · 2026Review
- Constipation in critically ill adults.World journal of gastrointestinal pathophysiology · 2025Review
- Gastrointestinal complications in intensive care.Medical review (2021) · 2025Review
- Article
- Impact of Glucagon-Like Peptide-1 Receptor Agonist Exposure on Gastrointestinal Outcomes Among ICU Patients: A Multicenter Matched Cohort Study.Critical care explorations · 2025Article
- The Japanese Critical Care Nutrition Guideline 2024.Journal of intensive care · 2025Review
- The association between defecation frequency and mortality in critically ill patients with suspected sepsis in Israel.Acute and critical care · 2025Article
- Article
- Development and validation of a clinical score for early diagnosis of constipation in critically ill children.Scientific reports · 2023Observational
- Effects of acupressure on intestinal function in patients with coronary artery bypass graft surgery: a randomized clinical trial.Gastroenterology and hepatology from bed to bench · 2023Article
- Gastrointestinal dysfunction is associated with mortality in severe burn patients: a 10-year retrospective observational study from South China.Military Medical Research · 2022Observational
- Epidemiology of constipation in critically ill patients and its impact on in-hospital mortality: a retrospective observational study.Journal of anesthesia · 2022Observational
- Re-examining chemically defined liquid diets through the lens of the microbiome.Nature reviews. Gastroenterology & hepatology · 2021Review
- The effect of opioids on gastrointestinal function in the ICU.Critical care (London, England) · 2021Review
- Erratum to: Comments to: Risk factors for late defecation and its association with the outcomes of critically ill patients: a retrospective observational study.Journal of intensive care · 2016Article
- Comments to: Risk factors for late defecation and its association with the outcomes of critically ill patients: a retrospective observational study.Journal of intensive care · 2016Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLate defecation was recently reported to be associated with worse clinical outcomes in critically ill patients. However, more research is needed to examine the causes and clinical significance of late defecation. The objectives of this study were to investigate the risk factors for late defecation and its association with the outcomes of intensive care unit (ICU) patients.
methodsPatients in an ICU for ≥7 days between January and December 2011 were retrospectively assessed. Based on the time between admission and the first defecation, they were assigned to early (<6 days; n = 186) or late (≥6 days; n = 96) defecation groups. Changes in clinical variables between admission and ICU day 7 were assessed to investigate the effects of late defecation. The clinical outcomes were ICU mortality, length of ICU stay, and length of mechanical ventilation.
resultsLate enteral nutrition (odds ratio (OR) 3.42; 95 % confidence interval (CI) 1.88-6.22; P < 0.001), sedatives (OR 3.07; 95 % CI 1.71-5.52; P < 0.001), and surgery (OR 1.86; 95 % CI 1.01-3.42; P = 0.047) were the independent risk factors for late defecation. The median (interquartile) changes in body temperature (0.3 [-0.4 to 1.0] vs 0.7 [0.1 to 1.5] °C; P = 0.004), serum C-reactive protein concentration (1.6 [-0.5 to 6.6] vs 3.5 [0.7 to 8.5] mg/dL; P = 0.035), and Sequential Organ Failure Assessment score (-1 [-2 to 1] vs 0 [-1 to 2]; P = 0.008) between admission and ICU day 7 were significantly greater in the late defecation group than in the early defecation group. ICU stay was significantly longer in the late defecation group (12 [9 to 19] vs 16 [10 to 23] days; P = 0.021), whereas ICU mortality and the length of mechanical ventilation were similar in both groups.
conclusionsLate enteral nutrition, sedatives, and surgery were independent the risk factors for late defecation in critically ill patients. Late defecation was associated with prolonged ICU stay.
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