Evidence map›Paper›PMID 27134656›Full record

ArticleTherapeutic advances in gastroenterology2016

Predictors for postoperative esophageal stricture after balloon-based radiofrequency ablation for early esophageal squamous neoplasia: a multicenter validation study.

Wen-Lun Wang, I-Wei Chang, Chien-Chuan Chen, Wei-Lun Chang, Yin-Yi Chu, Ping-Hsiu Wu, Wei-Chen Tai, Po-Yueh Chen, Ping-Hsin Hsieh, Chen-Shuan Chung and 4 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05768282 (Administration of Oral Prednisolone to Prevent Esophageal Stricture After Balloon-type Radiofrequency Ablation for Long-segment Esophageal Neoplasia), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05768282 phase4unknown statusnot on this map

Administration of Oral Prednisolone to Prevent Esophageal Stricture After Balloon-type Radiofrequency Ablation for Long-segment Esophageal Neoplasia

TypeinterventionalSponsorE-DA HospitalRan2016 to 2025Enrolled50ConditionsEsophageal Neoplasms, Esophagus StenosisArmsOral prednisolone (30mg/day) for 28 days
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Usefulness of argon plasma coagulation for superficial esophageal squamous cell neoplasia in patients at high risk or with limited endoscopic resectability.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 1 country.

Wen-Lun WangDepartment of Internal Medicine, Da Hospital/I-Shou University, Kaohsiung, Taiwan.
I-Wei ChangDepartment of Pathology, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan.
Chien-Chuan ChenDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Wei-Lun ChangDepartment of Internal Medicine, National Cheng Kung University Medical Center, Tainan, Taiwan.
Yin-Yi ChuDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Ping-Hsiu WuDepartment of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Wei-Chen TaiDepartment of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Po-Yueh ChenDepartment of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
Ping-Hsin HsiehDepartment of Gastroenterology, Chimei Medical Center, Tainan, Taiwan.
Chen-Shuan ChungDepartment of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Chi-Yang ChangDepartment of Internal Medicine, Da Hospital/I-Shou University, Kaohsiung, Taiwan.
Jaw-Town LinDepartment of Internal Medicine, Da Hospital/I-Shou University, Kaohsiung, Taiwan.
Hsiu-Po WangDepartment of Internal Medicine, National Taiwan University, No. 1, Changde St., Zhongzheng Dist., Taipei City 10048, Taiwan.
Ching-Tai LeeDepartment of Internal Medicine, E-Da Hospital/I-Shou University, No.1 Yida Road, Jiaosu Village, Yanchao District, Kaohsiung City 82445, Taiwan.
I-Shou University · TWChang Gung Memorial Hospital · TWChang Gung University · TWChia-Yi Christian Hospital · TWChi Mei Medical Center · TWE-Da Hospital · TWFar Eastern Memorial Hospital · TWNational Cheng Kung University · TWNational Taiwan University · TWNational Taiwan University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndoscopic radiofrequency ablation (RFA) is a rapidly evolving therapeutic modality for early flat esophageal squamous cell neoplasms (ESCNs), but the risk factors for postoperative stricture have not been elucidated. The objective of this study was to identify and validate a predictor for post-RFA stenosis.

methodsWe consecutively enrolled patients with flat-type 'large' (length no less than 3 cm extending no less than half the circumference of the esophagus), early ESCNs, treated with balloon-based RFA (12 J/cm(2)-clean-12 J/cm(2) regimen). The tumor and technical factors for postoperative stricture were investigated and we validated the results externally with a society-based multicenter cohort using the same ablation regimen.

resultsA total of 51 patients were enrolled (30 in the development set and 21 in the validation set). The complete remission rate at 12 months was 93%, and the rates of perforation and postoperative stenosis were 0% and 17%, respectively. Patients with post-RFA stenosis had a significantly larger longitudinal tumor size (mean 115 versus 61 mm, p = 0.003). There were no significant differences in age, body mass index, tumor circumferential extension, pretreatment histological grade, treatment efficacy or size of balloon catheter between the groups with or without stenosis. The optimal cut-off value was set as 9 cm to predict post-RFA stenosis by receiver operating characteristic curve [area under curve (AUC) = 0.881], which was then confirmed to be a reliable predictor by multivariate analysis (odds ratio, 12.7, 95% confidence interval, 1.18-136.28, p = 0.03) and have a good predictive performance in the validation set (AUC = 0.876).

conclusionsThe most frequent adverse event of RFA was esophageal stenosis, for which the longitudinal tumor size was a significant predictive factor. Early intervention or prevention for stricture should be applied for those with long segment (⩾9 cm) ESCNs.

Indexed as

adverse eventendoscopic ultrasoundesophageal squamous cell neoplasiaradiofrequency ablationstricture

Identifiers

PMID27134656
PMCPMC4830103
OpenAlexW2341285763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.