Evidence map›Paper›PMID 27134415›Full record

ArticleMaterials science & engineering. R, Reports : a review journal2015

Stimulus-responsive hydrogels: Theory, modern advances, and applications.

Michael C Koetting, Jonathan T Peters, Stephanie D Steichen, Nicholas A Peppas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials science & engineering. R, Reports : a review journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 271 papers.

0numbers the graph read from it
0cells of the map it votes in
271citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

271 citing papers in PubMed.

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211 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael C KoettingMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, United States; Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX 78712, United States.
Jonathan T PetersMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, United States; Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX 78712, United States.
Stephanie D SteichenDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, United States; Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX 78712, United States.
Nicholas A PeppasMcKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, United States; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, United States; College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, United States; Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin, Austin, TX 78712, United States.

Funding

pH Sensitive Complex Hydrogels for Protein Drug ReleaseR01EB000246 · NIBIB · UNIVERSITY OF TEXAS AUSTIN · PI LOWMAN, ANTHONY M, PEPPAS, NICHOLAS A · 2002 to 2014
$3.8M
NIBIB NIH HHS R01 EB000246
6 · The paper itself

Abstract

Over the past century, hydrogels have emerged as effective materials for an immense variety of applications. The unique network structure of hydrogels enables very high levels of hydrophilicity and biocompatibility, while at the same time exhibiting the soft physical properties associated with living tissue, making them ideal biomaterials. Stimulus-responsive hydrogels have been especially impactful, allowing for unprecedented levels of control over material properties in response to external cues. This enhanced control has enabled groundbreaking advances in healthcare, allowing for more effective treatment of a vast array of diseases and improved approaches for tissue engineering and wound healing. In this extensive review, we identify and discuss the multitude of response modalities that have been developed, including temperature, pH, chemical, light, electro, and shear-sensitive hydrogels. We discuss the theoretical analysis of hydrogel properties and the mechanisms used to create these responses, highlighting both the pioneering and most recent work in all of these fields. Finally, we review the many current and proposed applications of these hydrogels in medicine and industry.

Indexed as

BiosensorsChemically-responsiveDrug deliveryElectrically-responsiveHydrogelsMolecularly imprinted polymersPhoto-responsivepH responsivePolymersScaffoldsShear stressSmart materialsStimulus-responsiveSwellingTemperature responsiveTissue engineering

Identifiers

PMID27134415
PMCPMC4847551

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.