Evidence map›Paper›PMID 27134176›Full record

ArticleCell reports2016

Targeted Delivery of Immunomodulators to Lymph Nodes.

Jamil Azzi, Qian Yin, Mayuko Uehara, Shunsuke Ohori, Li Tang, Kaimin Cai, Takaharu Ichimura, Martina McGrath, Omar Maarouf, Eirini Kefaloyianni and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Intraorgan and targeted nanodelivery in organ transplantation of nonhuman primates.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  3. Article
  4. Unlocking Transplant Tolerance with Biomaterials.Advanced healthcare materials · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Lymph node targeting for immunotherapy.Immuno-oncology technology · 2023
    Review
  13. Article
  14. Review
  15. Review
  16. CaCOJournal of nanobiotechnology · 2023
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Jamil AzziTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Qian YinDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA.
Mayuko UeharaTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Shunsuke OhoriTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Li TangDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA.
Kaimin CaiDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA.
Takaharu IchimuraTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Martina McGrathTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Omar MaaroufTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Eirini KefaloyianniTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Scott LoughheadDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Jarolim PetrDepartment of Pathology, Clinical Laboratories Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Qidi SunDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA.
Mincheol KwonDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA.
Stefan TulliusDivision of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ulrich H von AndrianDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA; The Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Jianjun ChengDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA. Electronic address: jianjunc@illinois.edu.
Reza AbdiTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: rabdi@rics.bwh.harvard.edu.
Harvard University · USUniversity of Illinois Urbana-Champaign · USBrigham and Women's Hospital · USRagon Institute of MGH, MIT and Harvard · US

Funding

P3: Chemokine-Mediated T Cell Trafficking in HIV Transmission and Immune ResponseP01AI112521 · NIAID · HARVARD MEDICAL SCHOOL · PI SHARPE, ARLENE H. · 2014 to 2018
$9.8M
TRAINING PROGRAM IN ACADEMIC NEPHROLOGYT32DK007527 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 1986 to 2021
$8.8M
Generation and Function of NK Cell MemoryR01AI111595 · NIAID · HARVARD MEDICAL SCHOOL · PI VON ANDRIAN, ULRICH H · 2013 to 2017
$4.1M
Protection of organ transplant from ischemia reperfusion injuriesR01AI126596 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ABDI, REZA · 2016 to 2020
$2.6M
Developing Clinically Applicable, Cancer-Targeting Polymeric NanoconjugatesDP2OD007246 · OD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHENG, JIANJUN · 2010 to 2010
$2.4M
Ischemia-reperfusion injury in transplantation: novel cytoprotection strategiesR01AI091930 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ABDI, REZA · 2011 to 2015
$2.1M
Regulation of Skin Inflammation by Nociceptive Sensory NeuronsR01AR068383 · NIAMS · HARVARD MEDICAL SCHOOL · PI VON ANDRIAN, ULRICH H · 2015 to 2019
$1.9M
Training the Next Generation of Researchers in Cancer Nanotechnology at the NCI MR25CA154015 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BASHIR, RASHID, NARDULLI, ANN · 2010 to 2014
$1.5M
The novel role of the PI3Kγ and δ pathways in alloimmunityR56AI123270 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ABDI, REZA · 2016 to 2016
$404k
NCI NIH HHS R25 CA154015NIAID NIH HHS P01 AI112521NIAID NIH HHS R01 AI091930NIAID NIH HHS R01 AI111595NIAID NIH HHS R01 AI126596NIAID NIH HHS R56 AI123270NIAMS NIH HHS R01 AR068383NIDDK NIH HHS T32 DK007527NIH HHS DP2 OD007246
6 · The paper itself

Abstract

Active-targeted delivery to lymph nodes represents a major advance toward more effective treatment of immune-mediated disease. The MECA79 antibody recognizes peripheral node addressin molecules expressed by high endothelial venules of lymph nodes. By mimicking lymphocyte trafficking to the lymph nodes, we have engineered MECA79-coated microparticles containing an immunosuppressive medication, tacrolimus. Following intravenous administration, MECA79-bearing particles showed marked accumulation in the draining lymph nodes of transplanted animals. Using an allograft heart transplant model, we show that targeted lymph node delivery of microparticles containing tacrolimus can prolong heart allograft survival with negligible changes in tacrolimus serum level. Using MECA79 conjugation, we have demonstrated targeted delivery of tacrolimus to the lymph nodes following systemic administration, with the capacity for immune modulation in vivo.

Indexed as

Drug Delivery SystemsAnimalsAntibodiesAntigens, SurfaceCell ProliferationCytokinesDisease Models, AnimalGraft SurvivalHeart TransplantationImmunologic FactorsImmunosuppressive AgentsLymph NodesMembrane ProteinsMice, Inbred BALB CMice, Inbred C57BLMicrospheresAntibodiesAntigens, SurfaceCytokinesImmunologic FactorsImmunosuppressive AgentsL-selectin counter-receptorsMembrane ProteinsPolyesterspoly(lactide)Tacrolimus

Identifiers

PMID27134176
PMCPMC4973867
OpenAlexW2342745155

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.