ArticleInternational journal of obesity (2005)2016
Inter-relationships between the severity of metabolic syndrome, insulin and adiponectin and their relationship to future type 2 diabetes and cardiovascular disease.
Article in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Association of metabolic syndrome with cardiovascular outcomes in hypertensive patients: a systematic review and meta-analysis.Journal of endocrinological investigation · 2021Pooled it
- Childhood Risk Factors and Adulthood Cardiovascular Disease: A Systematic Review.The Journal of pediatrics · 2021Pooled it
- Heritability of the Severity of the Metabolic Syndrome in Whites and Blacks in 3 Large Cohorts.Circulation. Cardiovascular genetics · 2017Pooled it
- Effects of a 2-Year Primary Care Lifestyle Intervention on Cardiometabolic Risk Factors: A Cluster-Randomized Trial.Circulation · 2021Trial
- Use of a Metabolic Syndrome SeverityDiabetes care · 2018Trial
- Metabolic syndrome severity is related to perceived discrimination and stress in the all of us cohort.Comprehensive psychoneuroendocrinology · 2026Article
- Free testosterone independently predicts metabolic syndrome severity in U.S. adolescent girls aged 12-19 years.Journal of the Endocrine Society · 2026Article
- Impact of a combined lower carbohydrate and Mediterranean diet on metabolic syndrome severity: protocol for a randomised controlled trial.The British journal of nutrition · 2026Article
- Using metabolic syndrome severity in the "real world": Associations with diabetes and cardiovascular disease in all of us vs. NHANES.Metabolism open · 2025Article
- Association between Increased Age at Anterior Cruciate Ligament Reconstruction and Metabolic Syndrome.Orthopaedic journal of sports medicine · 2025Article
- Associations of Sleep Health and Metabolic Syndrome Severity in Black Individuals: The Jackson Heart Sleep Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Adiponectin signaling regulates urinary bladder function by blunting smooth muscle purinergic contractility.JCI insight · 2025Article
- Correlation of serum adiponectin with thyroid profile among metabolic syndrome patients with and without hypothyroidism.Bioinformation · 2025Article
- Article
- Association of Serum Leptin and Adiponectin Concentrations with Type 2 Diabetes Biomarkers and Complications Among Saudi Women.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Observational
- Severity of metabolic syndrome is greater among nonalcoholic adults with elevated ALT and advanced fibrosis.Nutrition research (New York, N.Y.) · 2021Article
- Use of metabolic syndrome severity to assess treatment with vitamin E and pioglitazone for non-alcoholic steatohepatitis.Journal of gastroenterology and hepatology · 2021Article
- Prediabetes in Adolescents: Prevalence, Management and Diabetes Prevention Strategies.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Review
- Predicting Long-Term Absence of Coronary Artery Calcium in Metabolic Syndrome and Diabetes: The MESA Study.JACC. Cardiovascular imaging · 2021Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe severity of the metabolic syndrome (MetS) is related to future incidence of type 2 diabetes (T2DM) and cardiovascular disease (CVD). However, the relationship between MetS severity and levels of fasting insulin and adiponectin-markers of insulin resistance-is unclear.
methodsWe used linear and logistic regression to analyze data from 711 participants of the Princeton Lipid Research Cohort with information regarding levels of insulin, adiponectin and MetS severity during 1998-2003 (mean age 39.5 years); 595 participants had MetS severity data from childhood (1973-1976, mean age 12.9 years) and 417 had updated disease status from 2010 to 2014 (mean age 50.9 years).
resultsChildhood MetS Z-scores were positively associated with adult insulin levels (P<0.001) and negatively associated with adiponectin levels (P=0.01). In individual analyses, higher insulin levels and MetS Z-score as adults were related to higher odds of incident diabetes and CVD over the next 11.2 years (all P<0.001), whereas lower adiponectin levels were only related to odds of future T2DM (P<0.0001). In a model including insulin, adiponectin and MetS Z-score, adiponectin was not linked to future disease; both insulin (P=0.027) and MetS Z-score (P=0.002) were related to risk of future T2DM, while only MetS Z-score was related to future CVD (P<0.001).
conclusionsThe severity of MetS exhibits long-term links to levels of insulin and adiponectin, suggesting potential genetic and environmental influences on insulin resistance over time. As a long-term predictor of T2DM and CVD, the severity of MetS exhibited consistent independent correlations. This supports clinical utility in evaluating MetS severity as a predictor of risk for future disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.