ArticleCellular & molecular immunology2018
NPR-9 regulates the innate immune response in Caenorhabditis elegans by antagonizing the activity of AIB interneurons.
Article in Cellular & molecular immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 78 citations in OpenAlex.
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- Pseudomonas aeruginosa modulates both Caenorhabditis elegans attraction and pathogenesis by regulating nitrogen assimilation.Nature communications · 2024Article
- Revealing neural dynamical structure ofiScience · 2024Article
- Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans.Molecular and cellular endocrinology · 2024Article
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- Antibacterial activity of cinnamon essential oil and its main component of cinnamaldehyde and the underlying mechanism.Frontiers in pharmacology · 2024Article
- Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans.Nature communications · 2023Article
- Paeoniflorin increases the survival of Pseudomonas aeruginosa infected Caenorhabditis elegans at the immunosuppression stage by activating PMK-1, BAR-1, and EGL-1 signals.Archives of pharmacal research · 2023Article
- Treatment with paeoniflorin increases lifespan ofFrontiers in pharmacology · 2023Article
- Exposure to Nanoplastic Particles EnhancesNanomaterials (Basel, Switzerland) · 2022Article
- Beneficial effect of Xuebijing againstFrontiers in pharmacology · 2022Article
- Pan-phylumFrontiers in endocrinology · 2022Article
- Biosafety assessment of Acinetobacter strains isolated from the Three Gorges Reservoir region in nematode Caenorhabditis elegans.Scientific reports · 2021Article
- Take a Walk to the Wild Side ofMicrobiology and molecular biology reviews : MMBR · 2021Review
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5 authors at 1 institution in 1 country.
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Abstract
npr-9 encodes a homologue of the gastrin-releasing peptide receptor (GRPR) and is expressed in AIB interneurons. In this study, we investigated the role of NPR-9 in the neuronal control of innate immunity using the model system Caenorhabditis elegans. After exposure to Pseudomonas aeruginosa PA14, npr-9(tm1652) mutants showed resistance to infection, decreased PA14 colonization and increased expression of immunity-related genes. Nematodes overexpressing NPR-9 exhibited increased susceptibility to infection, increased PA14 colonization and reduced expression of immunity-related genes. In nematodes, ChR2-mediated AIB interneuron activation strengthened the innate immune response and decreased PA14 colonization. Overexpression of NPR-9 suppressed the innate immune response and increased PA14 colonization in nematodes with the activation of AIB interneurons mediated by ChR2 or by expressing pkc-1(gf) in AIB interneurons. We, therefore, hypothesize that NPR-9 regulates the innate immune response by antagonizing the activity of AIB interneurons. Furthermore, expression of GRPR, the human homologue of NPR-9, could largely mimic NPR-9 function by regulating innate immunity in nematodes. Our results provide insight into the pivotal role of interneurons in controlling innate immunity and the complex biological functions of GRPRs.
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