ArticleCellular & molecular immunology2018
Poly-gamma-glutamic acid from Bacillus subtilis upregulates pro-inflammatory cytokines while inhibiting NLRP3, NLRC4 and AIM2 inflammasome activation.
Article in Cellular & molecular immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
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- Estrogen receptor β activation alleviates inflammatory bowel disease by suppressing NLRP3-dependent IL-1β production in macrophages via downregulation of intracellular calcium level.Journal of advanced research · 2025Article
- A Poly-γ-Glutamic Acid/ε-Polylysine Hydrogel: Synthesis, Characterization, and Its Role in Accelerated Wound Healing.Gels (Basel, Switzerland) · 2025Article
- The Progress of Immune Cells-induced Inflammatory Response in Gout.Current pharmaceutical design · 2025Review
- Nanomaterials modulate tumor-associated macrophages for the treatment of digestive system tumors.Bioactive materials · 2024Review
- TheNutrients · 2024Article
- Role of innate immunity in SARS-CoV-2 infection.Biosafety and health · 2023Review
- The Antimicrobial Effects of Colistin Encapsulated in Chelating Complex Micelles for the Treatment of Multi-Drug-Resistant Gram-Negative Bacteria: A Pharmacokinetic Study.Antibiotics (Basel, Switzerland) · 2023Article
- JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation.Scientific reports · 2022Article
- Korean Red Ginseng, a regulator of NLRP3 inflammasome, in the COVID-19 pandemic.Journal of ginseng research · 2022Review
- Immunomodulatory functional foods and their molecular mechanisms.Experimental & molecular medicine · 2022Review
- Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome.Cell death & disease · 2021Article
- Riboflavin, vitamin B2, attenuates NLRP3, NLRC4, AIM2, and non-canonical inflammasomes by the inhibition of caspase-1 activity.Scientific reports · 2020Article
- Fructose-arginine, a non-saponin molecule of Korean Red Ginseng, attenuates AIM2 inflammasome activation.Journal of ginseng research · 2020Review
- Characterization of equine inflammasomes and their regulation.Veterinary research communications · 2020Article
- Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases.Cell death & disease · 2020Article
- Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression.Journal of ginseng research · 2019Article
- Triggers of NLRC4 and AIM2 inflammasomes induce porcine IL-1β secretion.Veterinary research communications · 2018Article
- Role of inflammasome regulation on immune modulators.Journal of biomedical research · 2018Article
- Mercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activation.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Poly-gamma-glutamic acid (γ-PGA) is a natural, edible and non-toxic polymer synthesized by Bacillus subtilis and is suggested as a safe biomaterial for the use in hydrogels and vaccine adjuvants. However, the effect of γ-PGA on inflammasome activation has not yet been studied in macrophages. Inflammasomes, which are intracellular multi-protein complexes, promote acute and chronic inflammation via interleukin-1β or interleukin-18 maturation, and they are known targets for metabolic syndromes and cancer. In this study, we observed that γ-PGA attenuated NLRP3, NLRC4 and AIM2 inflammasome activation, whereas it upregulated pro-inflammatory cytokine expression in human and murine macrophages. Although γ-PGA had conflicting effects on cytokine production and maturation, it clearly alleviated the severity of lipopolysaccharide-induced endotoxin shock in an animal model. Thus, we suggest γ-PGA as a candidate to control inflammasome-mediated disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.