ArticleNeuron2016
Functional Properties of Dendritic Gap Junctions in Cerebellar Golgi Cells.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Cortical control of chandelier cells in neural codes.Frontiers in cellular neuroscience · 2022Pooled it
- Defining the electrical synapse.Nature reviews. Neuroscience · 2026Review
- Rod/Cone Gap Junctions: Plastic Electrical Synapses at the First Visual Synapse.Annual review of vision science · 2026Review
- Impact of Aii Amacrine Cell Rewiring in a Pathoconnectome-Based Computational Model of Early Retinal Degeneration.bioRxiv : the preprint server for biology · 2026Article
- Expression of group II mGluRs in the inferior colliculus, medial geniculate body, and auditory cortex increases with age.Neuroscience · 2025Article
- Gap Junctions May Have A Computational Function In The Cerebellum: A Hypothesis.Cerebellum (London, England) · 2024Article
- The components of an electrical synapse as revealed by expansion microscopy of a single synaptic contact.eLife · 2024Article
- When microscopy and electrophysiology meet connectomics-Steve Massey's contribution to unraveling the structure and function of the rod/cone gap junction.Frontiers in ophthalmology · 2023Review
- Model simulations unveil the structure-function-dynamics relationship of the cerebellar cortical microcircuit.Communications biology · 2022Article
- Analysis of rod/cone gap junctions from the reconstruction of mouse photoreceptor terminals.eLife · 2022Article
- Article
- Neurotransmitter content heterogeneity within an interneuron class shapes inhibitory transmission at a central synapse.Frontiers in cellular neuroscience · 2022Article
- The Amino Terminal Domain and Modulation of Connexin36 Gap Junction Channels by Intracellular Magnesium Ions.Frontiers in physiology · 2022Article
- Extracellular vesicles: catching the light of intercellular communication in fibrotic liver diseases.Theranostics · 2022Review
- On the Diverse Functions of Electrical Synapses.Frontiers in cellular neuroscience · 2022Review
- Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons.eLife · 2021Article
- Multidimensional population activity in an electrically coupled inhibitory circuit in the cerebellar cortex.Neuron · 2021Article
- Differential Contribution of Gap Junctions to the Membrane Properties of ON- and OFF-Bipolar Cells of the Rat Retina.Cellular and molecular neurobiology · 2021Article
- Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity.PLoS computational biology · 2020Article
- Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex.eLife · 2020Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The strength and variability of electrical synaptic connections between GABAergic interneurons are key determinants of spike synchrony within neuronal networks. However, little is known about how electrical coupling strength is determined due to the inaccessibility of gap junctions on the dendritic tree. We investigated the properties of gap junctions in cerebellar interneurons by combining paired somato-somatic and somato-dendritic recordings, anatomical reconstructions, immunohistochemistry, electron microscopy, and modeling. By fitting detailed compartmental models of Golgi cells to their somato-dendritic voltage responses, we determined their passive electrical properties and the mean gap junction conductance (0.9 nS). Connexin36 immunofluorescence and freeze-fracture replica immunogold labeling revealed a large variability in gap junction size and that only 18% of the 340 channels are open in each plaque. Our results establish that the number of gap junctions per connection is the main determinant of both the strength and variability in electrical coupling between Golgi cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.