ArticleNeuron2016
Network Homeostasis and State Dynamics of Neocortical Sleep.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 209 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
209 citing papers in PubMed, 373 citations in OpenAlex.
- Sleep EEG oscillations and synaptic plasticity in memory consolidation across NREM and REM sleep.Dialogues in clinical neuroscience · 2027Review
- Article
- Article
- Article
- Dentate gyrus interneurons modulate winner-take-all network dynamics in freely behaving mice.Neuron · 2026Article
- The default mode network exhibits circuit-specific selective vulnerability despite widespread amyloid burden in an animal model of Alzheimer's disease.Nature communications · 2026Article
- HIPPIE: a generative model for electrophysiological analysis across species, technologies, and modalities.Nature communications · 2026Article
- Enriched experience increases reciprocal synaptic connectivity and coding sparsity in higher-order cortex.Science advances · 2026Article
- Sleep lowers waking theta frequency in the rat hippocampus.Cell reports · 2026Article
- Sleep reveals dynamics integrating and segregating movement and stimulus representations in V1.Nature communications · 2026Article
- Article
- Respiratory pauses highlight sleep architecture in mice.Nature communications · 2026Article
- A reversible rat model of hyposmia affects respiration-linked brain oscillations and behavior.iScience · 2026Article
- Article
- Infraslow modulation of theta synchrony in the hippocampus circuit during REM sleep.Scientific reports · 2026Article
- Experimentally induced REM sleep fragmentation affects psychophysiological habituation to emotional stimuli.Sleep · 2026Article
- Neuronal spiking in the mammalian forebrain is dominated by a heterogeneous ground state.Neuron · 2026Article
- Cortical firing dynamics during micro-arousals vary with sleep/wake history and micro-arousal duration.Scientific reports · 2026Article
- Sharp wave-ripple clusters enhance hippocampal-neocortical engagement for memory consolidation.bioRxiv : the preprint server for biology · 2026Article
- A hippocampal 'sharp-wave sleep' state that is dissociable from cortical sleep.Nature neuroscience · 2026Article
149 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Sleep exerts many effects on mammalian forebrain networks, including homeostatic effects on both synaptic strengths and firing rates. We used large-scale recordings to examine the activity of neurons in the frontal cortex of rats and first observed that the distribution of pyramidal cell firing rates was wide and strongly skewed toward high firing rates. Moreover, neurons from different parts of that distribution were differentially modulated by sleep substates. Periods of nonREM sleep reduced the activity of high firing rate neurons and tended to upregulate firing of slow-firing neurons. By contrast, the effect of REM was to reduce firing rates across the entire rate spectrum. Microarousals, interspersed within nonREM epochs, increased firing rates of slow-firing neurons. The net result of sleep was to homogenize the firing rate distribution. These findings are at variance with current homeostatic models and provide a novel view of sleep in adjusting network excitability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.