ArticleInfectious diseases of poverty2016
First identification of kdr allele F1534S in VGSC gene and its association with resistance to pyrethroid insecticides in Aedes albopictus populations from Haikou City, Hainan Island, China.
Article in Infectious diseases of poverty, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52 citing papers in PubMed, 125 citations in OpenAlex.
- Insecticide resistance in mosquitoes: Current status, mechanism, monitoring and innovative strategies for sustainable vector control.Molecular biology reports · 2026Review
- Emergence and spatial distribution of knockdown resistance in a suburban population of Aedes albopictus.Parasites & vectors · 2026Article
- Emerging and regionally novel voltage-gated sodium channel mutations associated with pyrethroid resistance and altered binding affinity in Aedes albopictus (Skuse) from Northern Peninsular Malaysia.Parasites & vectors · 2026Article
- Metabolic resistance of the tiger mosquito to pyrethroid insecticides in La Réunion Island likely results from local adaptation.Genome biology and evolution · 2026Article
- Detection of insecticide resistance and knockdown resistance (Frontiers in cellular and infection microbiology · 2026Article
- Surveillance of pyrethroid resistance and detection of voltage-gated sodium channel gene mutations in Aedes albopictus populations from Shanghai, China.Parasites & vectors · 2025Article
- Molecular characterization of invasive Aedes albopictus (Diptera: Culicidae) populations in northwest Iran: Insights into origin, insecticide resistance, and Wolbachia infection.Parasites & vectors · 2025Article
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- Insecticide resistance dynamics inGigaByte (Hong Kong, China) · 2025Article
- Widespread geographic distribution of Aedes aegypti (Diptera: Culicidae) kdr variants in Panama.Journal of medical entomology · 2024Article
- Study on the cross-resistance of Aedes albopictus (Skuse) (Diptera: Culicidae) to deltamethrin and pyriproxyfen.Parasites & vectors · 2024Article
- The origin and insecticide resistance of Aedes albopictus mosquitoes established in southern Mozambique.Parasites & vectors · 2024Article
- Resistance to pyrethroids and the relationship between adult resistance and knockdown resistance (kdr) mutations in Aedes albopictus in dengue surveillance areas of Guizhou Province, China.Scientific reports · 2024Article
- Metabolic Resistance and Not Voltage-Gated Sodium Channel Gene Mutation Is Associated with Pyrethroid Resistance ofInsects · 2024Article
- Diversity and distribution of sodium channel mutations in Aedes albopictus (Diptera: Culicidae).Journal of medical entomology · 2024Article
- A novel strategy for screening mutations in the voltage-gated sodium channel gene of Aedes albopictus based on multiplex PCR-mass spectrometry minisequencing technology.Infectious diseases of poverty · 2023Article
- Insecticide resistance of Anopheles sinensis after elimination of malaria in Henan Province, China.Parasites & vectors · 2023Article
- High frequency of Voltage-gated sodium channel (VGSC) gene mutations in Aedes albopictus (Diptera: Culicidae) suggest rapid insecticide resistance evolution in Shanghai, China.PLoS neglected tropical diseases · 2023Article
- Evolution of knockdown resistance (Frontiers in cellular and infection microbiology · 2023Article
- Fitness costs associated with a GABA receptor mutation conferring dieldrin resistance in Aedes albopictus.Heredity · 2022Article
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10 authors at 2 institutions in 1 country.
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Abstract
backgroundAedes albopictus is distributed widely in China, as a primary vector of Dengue fever and Chikungunya fever in south of China. Chemical insecticide control is one of the integrated programmes to prevent mosquito-borne diseases. Long-term applications of pyrethroids have resulted in the development of resistance in Ae. albopictus populations in China. However, the susceptibility of Ae. albopictus to pyrethroids in Hainan Island was unclear. Knockdown resistance (kdr), caused by point mutations in the VGSC gene, is one of the mechanisms that confer resistance to DDT and pyrethroids. This study was to investigate the resistance level of Ae. albopictus populations in Haikou City to three pyrethroid insecticides, and elucidate the relationship between the resistant phenotype and kdr mutations.
methodsThe Aedes albopictus samples were collected in Xinbu Island (XI), Longtang Town (LT), Shishan Town (ST), Baishamen Park (BP), and Flower Market (FM) from Haikou City, Hainan Island, China. The larval susceptibility to deltamethrin, permethrin and beta-cypermethrin was tested by larval bioassays, and adult susceptibility to deltamethrin and DDT was determined by adult bioassays. The degree of resistance was determined by resistance ratio value (RR50 > 3) for larvae and by mortality for adult. The kdr alleles at codon 1534 of the VGSC gene were genotyped. The relationship between kdr genotypes and resistant phenotypes was analyzed by Chi-square test.
resultsOut of five populations, assessed by larval bioassays, XI was susceptible to deltamethrin and permethrin; LT was susceptible to permethrin and beta-cypermethrin; and ST was susceptible to permithrin. FM and BP both were resistant to all of the three pyrethroids, and FM showed the highest degree of resistance, with RR50 values from 65.17 to 436.36. A total of 493 individuals from the larval bioassays were genotyped for kdr alleles. Five alleles were detected, including two wildtype alleles, TTC(F) (67.04 %) and TTT(F) (0.41 %), and three mutant alleles, TGC(C) (0.30 %), TCC(S) (31.54 %) and TTG(L) (0.71 %). There was a clear correlation between mutant alleles (or F1534S) and resistant phenotypes (P < 0.01).
conclusionTwo novel kdr mutant alleles F1534S and F1534L were detected in the pyrethroid resistant populations of Ae. albopictus in Haikou Hainan, China. For the first time, the mutant F1534S was associated with pyrethroid resistance in Ae. albopictus.
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