ArticleHuman brain mapping2016
Axon density and axon orientation dispersion in children born preterm.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 62 citations in OpenAlex.
- Associations between mathematical skills and white matter microstructure in children born preterm.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2026Article
- In vivo mapping of infant brain microstructure with neurite orientation dispersion and density imaging.Brain structure & function · 2025Review
- Brain tissue microstructure in a prospective, longitudinal, population-based cohort of preterm and term-born young adults.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- White-Matter Connectivity and General Movements in Infants with Perinatal Brain Injury.Brain sciences · 2025Article
- Long-term brain structural and cognitive outcomes in a low-risk preterm-born sample.Scientific reports · 2024Article
- Perinatal influences on academic achievement and the developing brain: a scoping systematic review.Frontiers in psychology · 2024Article
- Increased white matter fibre dispersion and lower IQ scores in adults born preterm.Human brain mapping · 2024Article
- Multi-view fusion of diffusion MRI microstructural models: a preterm birth study.Frontiers in neuroscience · 2024Article
- White matter microstructure is differently associated with executive functioning in youth born with congenital heart disease and youth born preterm.Brain and behavior · 2023Article
- White matter microstructure predicts individual differences in infant fear (But not anger and sadness).Developmental science · 2023Article
- Applications of advanced diffusion MRI in early brain development: a comprehensive review.Brain structure & function · 2023Review
- A comparison of altered white matter microstructure in youth born with congenital heart disease or born preterm.Frontiers in neurology · 2023Article
- Atypical developmental trajectories of white matter microstructure in prenatal alcohol exposure: Preliminary evidence from neurite orientation dispersion and density imaging.Frontiers in neuroscience · 2023Article
- Neuroimaging of brain connectivity related to reading outcomes in children born preterm: A critical narrative review.Frontiers in pediatrics · 2023Review
- Diffuse excessive high signal intensity in the preterm brain on advanced MRI represents widespread neuropathology.NeuroImage · 2022Article
- Brain White Matter Development Over the First 13 Years in Very Preterm and Typically Developing Children Based on theNeurology · 2022Article
- Extremely preterm children and relationships of minor neurodevelopmental impairments at 6 years.Frontiers in psychology · 2022Article
- Early structural connectivity within the sensorimotor network: Deviations related to prematurity and association to neurodevelopmental outcome.Frontiers in neuroscience · 2022Article
- Development of brain white matter and math computation ability in children born very preterm and full-term.Developmental cognitive neuroscience · 2021Article
- Neuroimaging of Supraventricular Frontal White Matter in Children with Familial Attention-Deficit Hyperactivity Disorder and Attention-Deficit Hyperactivity Disorder Due to Prenatal Alcohol Exposure.Neurotoxicity research · 2021Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundVery preterm birth (VPT, <32 weeks' gestation) is associated with altered white matter fractional anisotropy (FA), the biological basis of which is uncertain but may relate to changes in axon density and/or dispersion, which can be measured using Neurite Orientation Dispersion and Density Imaging (NODDI). This study aimed to compare whole brain white matter FA, axon dispersion, and axon density between VPT children and controls (born ≥37 weeks' gestation), and to investigate associations with perinatal factors and neurodevelopmental outcomes.
methodsFA, neurite dispersion, and neurite density were estimated from multishell diffusion magnetic resonance images for 145 VPT and 33 control 7-year-olds. Diffusion values were compared between groups and correlated with perinatal factors (gestational age, birthweight, and neonatal brain abnormalities) and neurodevelopmental outcomes (IQ, motor, academic, and behavioral outcomes) using Tract-Based Spatial Statistics.
resultsCompared with controls, VPT children had lower FA and higher axon dispersion within many major white matter fiber tracts. Neonatal brain abnormalities predicted lower FA and higher axon dispersion in many major tracts in VPT children. Lower FA, higher axon dispersion, and lower axon density in various tracts correlated with poorer neurodevelopmental outcomes in VPT children.
conclusionsFA and NODDI measures distinguished VPT children from controls and were associated with neonatal brain abnormalities and neurodevelopmental outcomes. This study provides a more detailed and biologically meaningful interpretation of white matter microstructure changes associated with prematurity. Hum Brain Mapp 37:3080-3102, 2016. © 2016 Wiley Periodicals, Inc.
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