ArticleThe journal of allergy and clinical immunology. In practice
Changes in Food-Specific IgE Over Time in the National Health and Nutrition Examination Survey (NHANES).
Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- Temporal, Age, and Racial and Ethnic Trends in Allergen Consumption from 2-Day 24-Hour Recalls, NHANES 2003-2023.The journal of allergy and clinical immunology. In practice · 2025Article
- Sensitization to common foods and early vascular aging: associations and the mitigating effects of health behaviors.BMC public health · 2025Article
- Metabolomic profiles during early childhood and risk of food allergies and asthma in multiethnic children from a prospective birth cohort.The Journal of allergy and clinical immunology · 2024Article
- Lower socioeconomic status may help explain racial disparities in asthma and atopic dermatitis prevalence: A mediation analysis.The Journal of allergy and clinical immunology · 2024Article
- IgE to common food allergens is associated with cardiovascular mortality in the National Health and Examination Survey and the Multi-Ethnic Study of Atherosclerosis.The Journal of allergy and clinical immunology · 2024Article
- Food hypersensitivity: an examination of factors influencing symptoms and temporal changes in the prevalence of sensitization in an adult sample.European journal of clinical nutrition · 2023Article
- Changes in risk factors for food sensitization in early life: Analysis over a period of 10 years.Frontiers in immunology · 2023Article
- Allergic Sensitization Pattern in the Korean Dermatologic Patients.Annals of dermatology · 2022Article
- Food Allergies in Inner-City Schools: Addressing Disparities and Improving Management.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Review
- Relevance of Early Introduction of Cow's Milk Proteins for Prevention of Cow's Milk Allergy.Nutrients · 2022Review
- Industry influence in healthcare harms patients: myth or maxim?Breathe (Sheffield, England) · 2022Review
- The prevalence and temporal trends of food allergy among preschool children in Northern Thailand between 2010 and 2019.The World Allergy Organization journal · 2021Article
- Epidemiology and Burden of Food Allergy.Current allergy and asthma reports · 2020Review
- Maternal triacylglycerol signature and risk of food allergy in offspring.The Journal of allergy and clinical immunology · 2019Article
- Epidemiology of Cow's Milk Allergy.Nutrients · 2019Review
- Cockroach, dust mite, and shrimp sensitization correlations in the National Health and Nutrition Examination Survey.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Article
- The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States.Pediatrics · 2018Article
- Article
- Racial/ethnic and socioeconomic differences in self-reported food allergy among food-sensitized children in National Health and Nutrition Examination Survey III.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2016Article
- Balancing Tolerance or Allergy to Food Proteins.Trends in immunology · 2016Review
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundFood allergy prevalence appears to have recently risen, with larger increases among non-Hispanic blacks. However, it is unclear whether these trends represent shifts in recognition of food allergy or in sensitization.
objectiveThe objective of this study was to determine whether sensitization to common food allergens increased in US children from 1988-1994 to 2005-2006 and whether these trends differed by race and/or ethnicity.
methodsFood-specific immunoglobulin E (IgE; to peanut, milk, egg, and shrimp) was measured by ImmunoCAP in stored sera from subjects aged 6-19 in the National Health and Nutrition Examination Survey (NHANES) III (1988-1994) and was compared with NHANES 2005-2006. Sensitization to foods was defined as overall (IgE ≥ 0.35 kU/L), moderate level (IgE ≥ 2 kU/L), and high level (IgE ≥ commonly used 95% predictive values). Sensitization to individual and combined foods was compared between surveys, with analyses further stratified by race and/or ethnicity.
resultsA total of 7896 subjects (NHANES III: n = 4995, NHANES 2005-2006: n = 2901) were included. In NHANES III, the prevalence of food sensitization was 24.3% (95% confidence interval [CI]: 22.1-26.5) compared with 21.6% (95% CI: 19.5-23.7) in NHANES 2005-2006. There were no significant changes in the prevalence of any level of milk, egg, or peanut sensitization, but shrimp sensitization at all levels decreased markedly; overall sensitization NHANES III: 11.2% (95% CI: 10.0-12.5) versus NHANES 2005-2006: 6.1% (95% CI: 4.5-7.7). There was a trend toward the increased prevalence of moderate- and high-level sensitization to the combination of milk, egg, and peanut among non-Hispanic blacks but not other groups.
conclusionsIn contrast to our expectations, sensitization to common food allergens did not increase between the late 1980s/early 1990s and the mid-2000s among US 6-19 year olds, and in fact decreased to shrimp.
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