Evidence map›Paper›PMID 27132569›Full record

ArticleTrends in biochemical sciences2016

PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis.

Roberta Fiume, David R Jones, Nullin Divecha

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in biochemical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Roberta FiumeDIBINEM, University of Bologna, via Irnerio n 4840126, Bologna, Italy.
David R JonesAstraZeneca, Oncology iMED, Mereside, Alderley Park, Macclesfield, SK10 4TG, UK.
Nullin DivechaThe Inositide Laboratory, Centre for Biological Sciences, Highfield Campus, Southampton University, Southampton, SO17 1BJ, UK; INGM Istituto Nazionale Genetica Molecolare, Padiglione Romeo ed Enrica Invernizzi, IRCCS Ospedale Maggiore Policlinico, Via Francesco Sforza, 35 - 20122 Milano, Italy, C.F. / P.IVA 04175700964. 3. Electronic address: n.divecha@soton.ac.uk.
AstraZeneca (United Kingdom) · GBIstituto Nazionale Genetica Molecolare · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although guanine nucleotides are essential for cell growth, how their levels are sensed in mammalian cells is unknown. Sumita et al. show that PIP4K2B, a phosphoinositide kinase, is a molecular sensor that transduces changes in GTP into changes in the levels of the phosphoinositide PtdIns5P to modulate tumour cell growth.

Indexed as

Gene Expression Regulation, NeoplasticAdenosine TriphosphateAnimalsBinding SitesCell Line, TransformedCell ProliferationCell Transformation, NeoplasticFibroblastsGuanosine TriphosphateHumansIsoenzymesKineticsMiceMice, NudeMutationPhosphatidylinositol Phosphates1-phosphatidylinositol-4-phosphate 5-kinaseAdenosine TriphosphateGuanosine TriphosphateIsoenzymesphosphatidylinositol 5-phosphatePhosphatidylinositol PhosphatesPhosphotransferases (Alcohol Group Acceptor)

Identifiers

PMID27132569
OpenAlexW2343865728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.