Evidence map›Paper›PMID 27132523›Full record

ReviewNeurosurgical focus2016

Neurorestoration after stroke.

Tej D Azad, Anand Veeravagu, Gary K Steinberg

Open access · diamondAbstract readReview
In one paragraph

Review in Neurosurgical focus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. VCAM-1Neurochemical research · 2023
    Article
  12. Angiogenesis after ischemic stroke.Acta pharmacologica Sinica · 2023
    Review
  13. Article
  14. Article
  15. Towards translational optogenetics.Nature biomedical engineering · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tej D AzadDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California.
Anand VeeravaguDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California.
Gary K SteinbergDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California.
Stanford University · US

Funding

Paracrine and synaptic mechanisms underlying recovery using human stem cell theraR01NS058784 · NINDS · STANFORD UNIVERSITY · PI STEINBERG, GARY K · 2008 to 2023
$6.6M
NINDS NIH HHS R01 NS058784
6 · The paper itself

Abstract

Recent advancements in stem cell biology and neuromodulation have ushered in a battery of new neurorestorative therapies for ischemic stroke. While the understanding of stroke pathophysiology has matured, the ability to restore patients' quality of life remains inadequate. New therapeutic approaches, including cell transplantation and neurostimulation, focus on reestablishing the circuits disrupted by ischemia through multidimensional mechanisms to improve neuroplasticity and remodeling. The authors provide a broad overview of stroke pathophysiology and existing therapies to highlight the scientific and clinical implications of neurorestorative therapies for stroke.

Indexed as

AnimalsCell TransplantationElectric Stimulation TherapyHumansNeuronal PlasticityRecovery of FunctionStrokeBCI = brain-computer interfacebrain-computer interfaceexogenous stem cellsG-CSF = granulocyte colony-stimulating factorMSC = mesenchymal stem cellneuroplasticityNPC = neural progenitor cellNSC = neural stem cellNT2N = Ntera2/D1 neuron-likeoptogeneticsPSD-95 = postsynaptic density-95RCT = randomized controlled trialtDCS = transcranial direct current stimulationTMS = transcranial magnetic stimulationtPA = tissue plasminogen activator

Identifiers

PMID27132523
PMCPMC4916840
OpenAlexW2343476684

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.