ArticleParkinsonism & related disorders2016
Hypertrophic olivary degeneration: A clinico-radiologic study.
Article in Parkinsonism & related disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Guillain-Mollaret triangle: a key player in motor coordination and control with implications for neurological disorders.Neurosurgical review · 2023Pooled it
- Progression of a pontine cavernous malformation and delayed bilateral hypertrophic olivary degeneration: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Inferior olive lesions in autoimmune glial fibrillary acidic protein astrocytopathy: a report of two cases.BMC neurology · 2026Article
- Vestibular Rehabilitation of Patient with Hypertrophic Olivary Degeneration: A Case Report.Journal of the American Academy of Audiology · 2025Article
- Hypertrophic olivary degeneration after posterior cranial fossa tumor resection in adults: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Unusual co-occurrence of hypertrophic inferior olivary degeneration with infratentorial cavernomatosis and orbital cavernous hemangioma.Radiology case reports · 2025Article
- Article
- Palatal myoclonus and hypertrophic olivary degeneration following wernekinck commissure syndrome: a case report.BMC neurology · 2023Article
- The first case report of spinocerebellar ataxia type-40 in India: novel phenotypic and radiological (bilateral olivary degeneration) features and a comprehensive review of this remarkable radiological sign.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Hypertrophic olivary degeneration: a description of four cases of and a literature analysis.Quantitative imaging in medicine and surgery · 2022Article
- Qualitative and quantitative detectability of hypertrophic olivary degeneration in T2, FLAIR, PD, and DTI: A prospective MRI study.Frontiers in neurology · 2022Article
- Bilateral hypertrophıc olivary degeneration: case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Holmes tremor and palatal tremor in hypertrophic olivary degeneration: involvement of brainstem.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Bilateral Hypertrophic Olivary Degeneration Following Brainstem Insult: A Retrospective Review and Examination of Causative Pathology.Neuroscience insights · 2021Review
- Hypertrophic olivary degeneration concomitant with bilateral middle cerebellar peduncles Wallerian degeneration following unilateral pontine infarction.BMC neurology · 2020Article
- Article
- Palatal Tremor - Pathophysiology, Clinical Features, Investigations, Management and Future Challenges.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Review
- Segmental Myorhythmia with Palatal Tremor Due to Bilateral Hypertrophic Olivary Degeneration in Wilson Disease.Movement disorders clinical practice · 2020Article
- High-Frequency Palatal Tremor and Stimulus-Sensitive Leg Myoclonus with Degeneration of Inferior Olivary Nuclei in Celiac Disease.Movement disorders clinical practice · 2020Article
- Combined hypertrophic olivary degeneration and Wallerian degeneration of the bilateral middle cerebellar peduncles: a case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
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5 authors.
Funding
Abstract
introductionThe frequency and causes of hypertrophic olivary degeneration (HOD) are unknown. We compared the clinical and radiological characteristics of unilateral HOD and bilateral HOD.
methodsWe performed a search of a radiologic report database for patients who were radiologically diagnosed as having HOD. This database includes the patients examined at the Mayo Clinic in Florida and Arizona. We used the search terms "hypertrophic olivary degeneration", "HOD", and "olivary" in the reports recorded from 1995 to 2015. Pertinent medical records and magnetic resonance imaging (MRI) scans of the brain for those with HOD were reviewed retrospectively.
resultsWe identified 142 MRI studies on 95 cases who had radiologically proven HOD, 39 cases had unilateral HOD and 56 with bilateral HOD. In symptomatic cases, the most common symptom was ataxia. Palatal tremor was observed in almost half of all HOD cases. While cerebrovascular diseases were the most frequent etiology in both types of HOD (n = 24, 62% in unilateral; n = 17, 30% in bilateral), more than half of bilateral HOD cases had an unknown etiology (52%, n = 29), whereas only 13% (n = 5) of the unilateral cases had an unknown etiology (χ(2) test, P < 0.001). The lesions of unilateral HOD had a tendency to improve radiologically over time, whereas those associated with bilateral HOD were likely to worsen (χ(2) test, P < 0.05).
conclusionsOur study showed that bilateral HOD is more common than unilateral HOD. Half of bilateral HOD cases had no obvious cause and some worsened over time. This may implicate a possible primary neurodegenerative process.
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