Evidence map›Paper›PMID 27132177›Full record

ArticleWorld neurosurgery2016

Analysis of Multiple Intracranial Aneurysms with Different Outcomes in the Same Patient After Endovascular Treatment.

Linkai Jing, Jian Liu, Ying Zhang, Nikhil Paliwal, Hui Meng, Shengzhang Wang, Xinjian Yang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World neurosurgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Linkai JingBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jian LiuBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ying ZhangBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Nikhil PaliwalDepartment of Mechanical & Aerospace Engineering, University at Buffalo, The State University of New York, Buffalo, New York; Toshiba Stroke and Vascular Research Center, University at Buffalo, The State University of New York, Buffalo, New York.
Hui MengDepartment of Mechanical & Aerospace Engineering, University at Buffalo, The State University of New York, Buffalo, New York; Toshiba Stroke and Vascular Research Center, University at Buffalo, The State University of New York, Buffalo, New York; Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, New York.
Shengzhang WangDepartment of Mechanics and Engineering Science, Fudan University, Shanghai, China.
Xinjian YangBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address: yang-xj@163.net.
Capital Medical University · CNToshiba (United States) · USFudan University · CN

Funding

Virtual Intervention of Intracranial AneurysmsR01NS091075 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MENG, HUI · 2015 to 2019
$1.7M
NINDS NIH HHS R01 NS091075
6 · The paper itself

Abstract

backgroundAneurysm recanalization after coiling, with or without stent assistance, is a major issue in the endovascular management of intracranial aneurysms. Multiple intracranial aneurysms with different outcomes after endovascular treatment may represent a useful disease model in which patient-specific risk factors can be balanced to investigate possible features linked to aneurysm recanalization. In the present study, we evaluated the impact of aneurysm-specific, treatment-related, and hemodynamics-related factors on multiple aneurysms and to explore the reason why one aneurysm recanalized and the other did not.

methodsBetween 2010 and 2015, 763 multiple intracranial aneurysms in 326 patients were diagnosed by digital subtraction angiography. We retrospectively collected and analyzed 13 pairs of multiple aneurysms with different outcomes (recanalized or stable) in the same patient. Patient-specific models were constructed and analyzed by a computational fluid dynamics method. The virtual stent deployment method was used, and the coils were simulated by a porous medium model. Factors were evaluated for significance with respect to recanalization.

resultsAneurysm size (P = 0.021), neck width (P = 0.027), ruptured aneurysms (P = 0.002), reduction ratio of averaged velocity (P = 0.008), and wall shear stress (P = 0.024) were significantly associated with aneurysm recanalization. By contrast, the aneurysm location, all of treatment-related factors (packing density, duration of follow-up, stent use, initial angiographic result) and the reduction ratio of averaged pressure were not significantly associated (P > 0.05).

conclusionsSmall aneurysm size and neck width, unruptured aneurysm, and perianeurysmal hemodynamics with marked reduction may be important factors associated with the midterm durability of aneurysm embolization.

Indexed as

AdultAneurysm, RupturedAngiography, Digital SubtractionCarotid Artery DiseasesCerebral AngiographyCerebral RevascularizationEndovascular ProceduresFemaleHumansIntracranial AneurysmMaleMiddle AgedReoperationRetrospective StudiesStentsTreatment OutcomeCerebral hemodynamicsEndovascular treatmentIntracranial aneurysmsRecanalization

Identifiers

PMID27132177
PMCPMC4955706
OpenAlexW2343344249

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.