ArticleJournal of neuro-oncology2016
Parameters influencing local control of meningiomas treated with radiosurgery.
Article in Journal of neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Efficacy of radiotherapy and stereotactic radiosurgery as adjuvant or salvage treatment in atypical and anaplastic (WHO grade II and III) meningiomas: a systematic review and meta-analysis.Neurosurgical review · 2023Pooled it
- Incidence of radiation necrosis following different radiotherapy fractionation schedules for intracranial meningiomas.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- The Rationale for Early Adjuvant Radiotherapy After Gross Total Resection of Atypical Meningioma.Neurosurgery · 2025Article
- Stereotactic Radiosurgery for Recurrent Meningioma: A Systematic Review of Risk Factors and Management Approaches.Cancers · 2025Review
- Paradoxical evolution of spheno-orbital meningioma after cessation of progestin treatment.Surgical neurology international · 2025Article
- Meningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients.Neuro-oncology · 2024Review
- Proton therapy for intracranial meningioma: a single-institution retrospective analysis of efficacy, survival and toxicity outcomes.Journal of neuro-oncology · 2024Article
- Radiosurgery in Grade II and III Meningiomas: A Systematic Review and Meta-Analysis.Journal of personalized medicine · 2024Review
- Radiotherapy dose escalation for high-risk meningiomas after subtotal resection.Neuro-oncology · 2024Article
- Radiotherapy and radiosurgery for meningiomas.Neuro-oncology advances · 2023Article
- Radiotherapy for Meningioma.Advances in experimental medicine and biology · 2023Review
- Ten-year follow-up after Gamma Knife radiosurgery of meningioma and review of the literature.Acta neurochirurgica · 2020Review
- Proton Therapy for Intracranial Meningioma for the Treatment of Primary/Recurrent Disease Including Re-Irradiation.Frontiers in oncology · 2020Review
- Linear Accelerator-Based Radiosurgery of Grade I Intracranial Meningiomas.World neurosurgery: X · 2019Article
- Surgical Outcomes, Complications, and Management Strategies for Foramen Magnum Meningiomas.Journal of neurological surgery. Part B, Skull base · 2019Article
- Advances in multidisciplinary therapy for meningiomas.Neuro-oncology · 2019Review
- Salvage therapy outcomes for atypical meningioma.Journal of neuro-oncology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify parameters that influence local control after stereotactic radiosurgery (SRS) for meningiomas we retrospectively analyzed all meningiomas treated with Gamma Knife SRS at our institution from 1991 to 2007. Endpoints were measured from the date of SRS and estimated using the Kaplan-Meier method; subgroups were compared with log-rank tests. Sex, performance status, age, SRS setting, radiation dose, grade, volume and location were evaluated with univariate and multivariate Cox proportional hazards analyses. Of 280 patients with 438 tumors, 264 patients with clinical follow-up and 406 tumors with imaging follow-up were analyzed (median follow-up: 75.9 months). Thirty-seven percent of the tumors had no tissue diagnosis, 32 % were benign (grade I), 12 % atypical (grade II), and 19 % malignant (grade III). Five-year freedom from progression (FFP) was 97 % for presumed meningiomas, 87 % for grade I tumors, 56 % for grade II tumors, and 47 % for grade III tumors (p < 0.0001). Five-year FFP probabilities for upfront SRS versus SRS at recurrence after surgery versus SRS at recurrence after RT were 97, 86, and 38 %, respectively (p < 0.0001). Univariate analysis revealed that higher grade, larger target volume (median diameter: 2.4 cm) and SRS setting were associated with poorer FFP. Only target volume and SRS setting remained significant on multivariate analysis. Local control of presumed and grade I meningiomas is excellent with Gamma Knife SRS, but is suboptimal with high-grade tumors as well as for those treated at recurrence after RT or of large volume.
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