ArticleAddictive behaviors2016
Neurocognitive, psychiatric, and substance use characteristics in opioid dependent adults.
Article in Addictive behaviors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Neurocognitive impairments and brain abnormalities resulting from opioid-related overdoses: A systematic review.Drug and alcohol dependence · 2021Pooled it
- Disparities and burden of illness among hospitalized cancer patients with opioid dependence.Medical oncology (Northwood, London, England) · 2026Article
- Cognition and Depression in American Indian Elders with Prescribed Opioid Use: Data from the Strong Heart Study.Journal of racial and ethnic health disparities · 2026Article
- The relationship between duration of access to intravenous oxycodone self-administration, economic demand for oxycodone, and cognition in rats.Psychopharmacology · 2026Article
- Hippocampal Volume and Brain Tau Pathology in Opioid Use Disorder: Associations with Non-Fatal Opioid Overdose.Addiction neuroscience · 2026Article
- The relationship between duration of access to intravenous oxycodone self-administration, economic demand for oxycodone, and cognition in rats.Research square · 2026Article
- Measurement of Impulsivity and Its Role in Drug Use Behaviours and Related Health, Harm and Treatment Outcomes Among People Who Use Illicit Drugs-A Scoping Review.International journal of mental health and addiction · 2026Article
- Using explainable machine learning to elucidate social and neurobehavioral risk factors linked to nonmedicinal opioid use in young adults.Scientific reports · 2025Article
- Brain network segregation is associated with drug use severity in individuals with opioid use disorder.Drug and alcohol dependence · 2025Article
- Comparing attention, impulsivity, and executive functions between patients with opiate use disorder: Buprenorphine maintenance treatment versus active users, in comparison with healthy controls.Indian journal of psychiatry · 2024Article
- Factors associated with cognitive flexibility in people with opioid-use disorder: a pilot study.Frontiers in psychiatry · 2024Article
- Effects of current smoking severity on brain gray matter volume in opioid use disorder - a voxel-based morphometry study.The American journal of drug and alcohol abuse · 2023Article
- Differential expression ofDrug and alcohol dependence reports · 2022Article
- Article
- Mitragynine improves cognitive performance in morphine-withdrawn rats.Psychopharmacology · 2022Article
- Neurocognitive, psychiatric, and substance use characteristics in a diverse sample of persons with OUD who are starting methadone or buprenorphine/naloxone in opioid treatment programs.Addiction science & clinical practice · 2021Article
- Electroencephalography-based cortical sources of working memory in the subjects with opioid addiction: A pilot study.The Indian journal of medical research · 2021Article
- Preference for and Efficacy of a PrEP Decision Aid for Women with Substance Use Disorders.Patient preference and adherence · 2021Article
- Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020Article
- The Opioid-Addicted Tetrapartite Synapse.Biological psychiatry · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
aimsTo describe neurocognitive function among opioid-dependent adults seeking buprenorphine treatment and to explore the impact of lifetime psychiatric conditions on neurocognitive function. To explore the additive interaction of patient-based characteristics that may help to inform treatment.
designCross-sectional assessment of neurocognitive function, substance use, and psychiatric characteristics of adults seeking buprenorphine treatment within substance use treatment centers in New York City.
participantsThirty-eight opioid-dependent adults seeking buprenorphine treatment. MEASUREMENTS: A comprehensive battery, which included measures of executive functioning, learning, memory, verbal fluency, attention, processing speed, and motor functioning were administered. The Wide Range Achievement Test-Third Edition, the Composite International Diagnostic Interview, and an audio computer assisted structured interview were also completed. Correlations and independent sample t-tests were used to ascertain group differences.
findingsThirty-nine percent of participants were impaired in global neurocognitive function (n=15). Over one third were impaired in either: learning (n=28), memory (n=26), executive functioning (n=17), motor functioning (n=17), attention/working memory (n=14) or verbal fluency (n=12). Lifetime history of alcohol dependence was associated with impairment in global neurocognitive, executive functioning, and motor functioning. Lifetime history of cocaine dependence was associated with impairment in executive functioning and motor functioning (all p's<0.05). Major depressive disorder history was not associated with neurocognitive impairment.
conclusionsAmong this sample of opioid-dependent adults, there were high rates of global and domain-specific neurocognitive impairment, with severe impairment in learning and memory. Lifetime alcohol and cocaine dependence were associated with greater neurocognitive impairment, particularly in executive functioning. Because executive functioning is critical for decision-making and learning/memory dysfunction may interfere with information encoding, these findings suggest that opioid-dependent adults may require enhanced support for medical decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.