ReviewTrends in immunology2016
Memory CD8(+) T Cells: Innate-Like Sensors and Orchestrators of Protection.
Review in Trends in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- RAS P21 Protein Activator 3 finetunes Type I immunity by limiting HCK-mediated STAT4 phosphorylation.Nature communications · 2026Article
- Article
- In vivo CRISPR screens identify CBX4 as an epigenetic regulator for cancer immunotherapy.The Journal of clinical investigation · 2026Article
- T Helper and Cytotoxic T Cells Play an Important Role in Acute Gastric Injury.Diseases (Basel, Switzerland) · 2025Article
- Exploring the microbial basis of postbiotic and paraprobiotic therapy in ulcerative colitis.Archives of microbiology · 2025Review
- HGF can reduce accumulation of inflammation and regulate glucose homeostasis in T2D mice.Journal of physiology and biochemistry · 2021Article
- Metabolic programs define dysfunctional immune responses in severe COVID-19 patients.Cell reports · 2021Article
- Article
- Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits.Nature communications · 2020Article
- Chemokine Signatures of Pathogen-Specific T Cells I: Effector T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Chemokine Signatures of Pathogen-Specific T Cells II: Memory T Cells in Acute and Chronic Infection.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Metabolic programs define dysfunctional immune responses in severe COVID-19 patients.medRxiv : the preprint server for health sciences · 2020Article
- Role of T Cells in Chikungunya Virus Infection and Utilizing Their Potential in Anti-Viral Immunity.Frontiers in immunology · 2020Review
- CD4Nature communications · 2019Article
- Vaccinia Virus BBK E3 Ligase Adaptor A55 Targets Importin-Dependent NF-κB Activation and Inhibits CD8Journal of virology · 2019Article
- Development of a Human Cytomegalovirus (HCMV)-Based Therapeutic Cancer Vaccine Uncovers a Previously Unsuspected Viral Block of MHC Class I Antigen Presentation.Frontiers in immunology · 2019Article
- The TNF Superfamily Molecule LIGHT Promotes the Generation of Circulating and Lung-Resident Memory CD8 T Cells following an Acute Respiratory Virus Infection.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-Dependent and CD4Frontiers in immunology · 2018Article
- Airway T cells protect against RSV infection in the absence of antibody.Mucosal immunology · 2018Article
- Hantavirus-Driven PD-L1/PD-L2 Upregulation: An Imperfect Viral Immune Evasion Mechanism.Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Recent findings have revealed roles for systemic and mucosa-resident memory CD8(+) T cells in the orchestration of innate immune responses critical to host defense upon microbial infection. Here we integrate these findings into the current understanding of the molecular and cellular signals controlling memory CD8(+) T cell reactivation and the mechanisms by which these cells mediate effective protection in vivo. The picture that emerges presents memory CD8(+) T cells as early sensors of danger signals, mediating protective immunity both through licensing of cellular effectors of the innate immune system and via the canonical functions associated with memory T cells. We discuss implications for the development of T cell vaccines and therapies and highlight important areas in need of further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.