Evidence map›Paper›PMID 27131362›Full record

ArticleNucleic acids research2016

miEAA: microRNA enrichment analysis and annotation.

Christina Backes, Qurratulain T Khaleeq, Eckart Meese, Andreas Keller

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 1 synthesis or guideline pooled it, 182 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Features of Complementary Interactions of BmiRNAs with mRNAs of Human Genes.International journal of molecular sciences · 2026
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  12. The RNA content of extracellular vesicles from gene-editedMolecular therapy. Methods & clinical development · 2025
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  18. Review
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60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christina BackesChair for Clinical Bioinformatics, Saarland University, Building E 2.1, 66123 Saarbrücken, Germany c.backes@mx.uni-saarland.de.
Qurratulain T KhaleeqChair for Clinical Bioinformatics, Saarland University, Building E 2.1, 66123 Saarbrücken, Germany.
Eckart MeeseInstitute of Human Genetics, Saarland University, Medical School, 66421 Homburg, Germany.
Andreas KellerChair for Clinical Bioinformatics, Saarland University, Building E 2.1, 66123 Saarbrücken, Germany.
Saarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Similar to the development of gene set enrichment and gene regulatory network analysis tools over a decade ago, microRNA enrichment tools are currently gaining importance. Building on our experience with the gene set analysis toolkit GeneTrail, we implemented the miRNA Enrichment Analysis and Annotation tool (miEAA). MiEAA is a web-based application that offers a variety of commonly applied statistical tests such as over-representation analysis and miRNA set enrichment analysis, which is similar to Gene Set Enrichment Analysis. Besides the different statistical tests, miEAA also provides rich functionality in terms of miRNA categories. Altogether, over 14 000 miRNA sets have been added, including pathways, diseases, organs and target genes. Importantly, our tool can be applied for miRNA precursors as well as mature miRNAs. To make the tool as useful as possible we additionally implemented supporting tools such as converters between different miRBase versions and converters from miRNA names to precursor names. We evaluated the performance of miEAA on two sets of miRNAs that are affected in lung adenocarcinomas and have been detected by array analysis. The web-based application is freely accessible at: http://www.ccb.uni-saarland.de/mieaa_tool/.

Indexed as

Gene Expression RegulationMolecular Sequence AnnotationUser-Computer InterfaceDatabases, GeneticGene Expression ProfilingGene OntologyHumansInternetMicroRNAsNeoplasmsNeurodegenerative DiseasesRNA PrecursorsMicroRNAsRNA Precursors

Identifiers

PMID27131362
PMCPMC4987907
OpenAlexW2343700030

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.