Evidence map›Paper›PMID 27131346›Full record

ArticleHuman molecular genetics2016

Oxidative metabolism and Ca2+ handling in isolated brain mitochondria and striatal neurons from R6/2 mice, a model of Huntington's disease.

James Hamilton, Jessica J Pellman, Tatiana Brustovetsky, Robert A Harris, Nickolay Brustovetsky

Open access · bronzeAbstract read
In one paragraph

Article in Human molecular genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Review
  3. Mitochondrial Calcium: Effects of Its Imbalance in Disease.Antioxidants (Basel, Switzerland) · 2022
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Cause or compensation?-Altered neuronal CaCNS neuroscience & therapeutics · 2018
    Review
  18. Oxidative metabolism and CaNeurochemistry international · 2017
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

James HamiltonDepartment of Pharmacology and Toxicology.
Jessica J PellmanDepartment of Pharmacology and Toxicology.
Tatiana BrustovetskyDepartment of Pharmacology and Toxicology.
Robert A HarrisDepartment of Biochemistry and Molecular Biology.
Nickolay BrustovetskyDepartment of Pharmacology and Toxicology nbrous@iu.edu.
Indiana University – Purdue University Indianapolis · USRichard L. Roudebush VA Medical Center · US

Funding

Mitochondrial Porin in Bioenergetic Defects in Huntingtons DiseaseR01NS078008 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI BRUSTOVETSKY, NICKOLAY · 2012 to 2015
$1.3M
NINDS NIH HHS R01 NS078008
6 · The paper itself

Abstract

Alterations in oxidative metabolism and defects in mitochondrial Ca

Indexed as

AnimalsBrainCalcium SignalingCell RespirationCorpus StriatumDisease Models, AnimalHumansHuntingtin ProteinHuntington DiseaseMiceMice, TransgenicMitochondriaNeostriatumNeuronsOxygenHTT protein, humanHuntingtin ProteinOxygen

Identifiers

PMID27131346
PMCPMC5181640
OpenAlexW2345152850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.