ArticleChemical senses2016
P2X2 Receptor Terminal Field Demarcates a "Transition Zone" for Gustatory and Mechanosensory Processing in the Mouse Nucleus Tractus Solitarius.
Article in Chemical senses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Molecular architecture of excitatory and inhibitory neurons in the first gustatory relay.bioRxiv : the preprint server for biology · 2026Article
- Somatostatin neurons in the rostral nucleus of the solitary tract are functionally heterogeneous.bioRxiv : the preprint server for biology · 2026Article
- Chemogenetic suppression of NST GABA neurons reveals inhibition of behavioral responses to sucrose and quinine.Physiology & behavior · 2025Article
- Response characteristics of oral mechanosensory neurons in the mouse trigeminal ganglion.Chemical senses · 2025Article
- Maternal diet during early gestation influences postnatal taste activity-dependent pruning by microglia.The Journal of experimental medicine · 2023Article
- The elusive cephalic phase insulin response: triggers, mechanisms, and functions.Physiological reviews · 2023Review
- A Novel Mechanism for T1R-Independent Taste Responses to Concentrated Sugars.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Regulation of Rostral Nucleus of the Solitary Tract Responses to Afferent Input by A-type K+ Current.Neuroscience · 2022Article
- Perturbation of amygdala/somatostatin-nucleus of the solitary tract projections reduces sensitivity to quinine in a brief-access test.Brain research · 2022Article
- Kv4 channel expression and kinetics in GABAergic and non-GABAergic rNST neurons.Journal of neurophysiology · 2020Article
- Optogenetic Stimulation of Type I GAD65The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Electrophysiological responses to sugars and amino acids in the nucleus of the solitary tract of type 1 taste receptor double-knockout mice.Journal of neurophysiology · 2020Article
- Neurons with diverse phenotypes project from the caudal to the rostral nucleus of the solitary tract.The Journal of comparative neurology · 2018Article
- Transcriptomes and neurotransmitter profiles of classes of gustatory and somatosensory neurons in the geniculate ganglion.Nature communications · 2017Article
- Microglia density decreases in the rat rostral nucleus of the solitary tract across development and increases in an age-dependent manner following denervation.Neuroscience · 2017Article
- 5-HTThe Journal of comparative neurology · 2017Article
- Immunocytochemical organization and sour taste activation in the rostral nucleus of the solitary tract of mice.The Journal of comparative neurology · 2017Article
- Inhibitory modulation of optogenetically identified neuron subtypes in the rostral solitary nucleus.Journal of neurophysiology · 2016Article
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2 authors at 2 institutions in 1 country.
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Abstract
Peripheral gustatory neurons express P2X2 purinergic receptors and terminate in the rostral portion of the nucleus tractus solitarius (rNTS), but a relationship between the P2X2 terminal field and taste evoked activity has not been established. Additionally, a portion of somatosensory neurons from the trigeminal nerve, which are devoid of P2X2 expression, also terminate in the lateral rNTS. We hypothesized that P2X2 receptor expression on afferent nerve endings could be used as an anatomical tool for segregating gustatory from mechanosensory responsive regions in the mouse rNTS. C57BL/6 mice were used to record extracellular activity from neurons within the rNTS and the laterally adjacent reticular formation and trigeminal nucleus. Histological reconstruction of electrolytic lesions indicated that gustatory activity coincided with electrode tracks that traversed through P2X2 terminal fields. Gustatory recordings made more rostral in the rNTS had receptive fields located in the anterior oral cavity (AO), whereas gustatory recordings made more caudal in the rNTS had receptive fields located in the posterior oral cavity (PO). Mechanosensory neurons with AO receptive fields were recorded near the lateral border of the P2X2 terminal field and became numerous on electrode tracks made lateral to the P2X2 terminal field. In contrast, mechanosensory responses with PO receptive fields were recorded within the P2X2 terminal field along with gustatory activity and transitioned to mechanosensory only outside the P2X2 terminal field. Collectively, our results indicate that the lateral border of the P2X2 terminal field, demarcates a faithful "transition zone," where AO responses transition from gustatory to mechanosensory.
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