ArticleJournal of the American Geriatrics Society2016
Drug Utilization and Inappropriate Prescribing in Centenarians.
Article in Journal of the American Geriatrics Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Primary care service use by end-of-life cancer patients: a nationwide population-based cohort study in the United Kingdom.BMC family practice · 2020Article
- Health of Spanish centenarians: a cross-sectional study based on electronic health records.BMC geriatrics · 2019Observational
- Frailty and Drug Safety at Older Ages.Drug safety · 2019Article
- Legacy Drug-Prescribing Patterns in Primary Care.Annals of family medicine · 2018Article
- Cohort profile: 'Centenari a Trieste' (CaT), a study of the health status of centenarians in a small defined area of Italy.BMJ open · 2018Article
- Evolution of the "fourth stage" of epidemiologic transition in people aged 80 years and over: population-based cohort study using electronic health records.Population health metrics · 2017Article
- Drug Utilization and Inappropriate Prescribing in Centenarians.Journal of the American Geriatrics Society · 2016Article
- Assessment of Comorbidity and Use of Prescription and Nonprescription Drugs in Patients Above 65 Years Attending Family Medicine Outpatient Clinics.Gerontology & geriatric medicineArticle
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo use primary care electronic health records (EHRs) to evaluate prescriptions and inappropriate prescribing in men and women at age 100.
designPopulation-based cohort study.
settingPrimary care database in the United Kingdom, 1990 to 2013.
participantsIndividuals reaching the age of 100 between 1990 and 2013 (N = 11,084; n = 8,982 women, n = 2,102 men). MEASUREMENTS: Main drug classes prescribed and potentially inappropriate prescribing according to the 2012 American Geriatrics Society Beers Criteria.
resultsAt the age of 100, 73% of individuals (79% of women, 54% of men) had received one or more prescription drugs, with a median of 7 (interquartile range 0-12) prescription items. The most frequently prescribed drug classes were cardiovascular (53%), central nervous system (CNS) (53%), and gastrointestinal (47%). Overall, 32% of participants (28% of men, 32% of women) who received drug prescriptions may have received one or more potentially inappropriate prescriptions, with temazepam and amitriptyline being the most frequent. CNS prescriptions were potentially inappropriate in 23% of individuals, and anticholinergic prescriptions were potentially inappropriate in 18% of individuals.
conclusionThe majority of centenarians are prescribed one or more drug therapies, and the prescription may be inappropriate for up to one-third of these individuals. Research using EHRs offers opportunities to understand prescribing trends and improve pharmacological care of the oldest adults.
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