ArticleAlcoholism, clinical and experimental research2016
Associations Between Cerebellar Subregional Morphometry and Alcoholism History in Men and Women.
Article in Alcoholism, clinical and experimental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Cerebellar aging is spatially heterogeneous and supports cognitive resilience in later life.Nature neuroscience · 2026Article
- Connectomics modeling of regional networks of white-matter fractional anisotropy to predict the severity of young adult drinking.Quantitative imaging in medicine and surgery · 2025Article
- Disrupted executive cerebro-cerebellar functional connectivity in alcohol use disorder.Alcohol, clinical & experimental research · 2024Article
- Astrocyte Reactivity and Neurodegeneration in the Female Rat Brain Following Alcohol Dependence.Neuroscience · 2023Article
- Brain volumes in alcohol use disorder: Do females and males differ? A whole-brain magnetic resonance imaging mega-analysis.Human brain mapping · 2023Article
- Disruption of cerebellar-cortical functional connectivity predicts balance instability in alcohol use disorder.Drug and alcohol dependence · 2022Article
- Intrinsic brain functional connectivity patterns in alcohol use disorder.Brain communications · 2022Article
- Sex Differences in Substance Use Disorders: A Neurobiological Perspective.Frontiers in global women's health · 2021Review
- Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.Journal of neuroscience research · 2021Review
- Brain responsivity to emotional faces differs in men and women with and without a history of alcohol use disorder.PloS one · 2021Article
- Trajectories of brain development reveal times of risk and factors promoting resilience to alcohol use during adolescence.International review of neurobiology · 2021Review
- Graded Cerebellar Lobular Volume Deficits in Adolescents and Young Adults with Fetal Alcohol Spectrum Disorders (FASD).Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Accelerated aging and motor control deficits are related to regional deformation of central cerebellar white matter in alcohol use disorder.Addiction biology · 2020Article
- Disturbed Cerebellar Growth Trajectories in Adolescents Who Initiate Alcohol Drinking.Biological psychiatry · 2020Article
- Hippocampal subfield volumes in abstinent men and women with a history of alcohol use disorder.PloS one · 2020Article
- Relations between cognitive and motor deficits and regional brain volumes in individuals with alcoholism.Brain structure & function · 2019Article
- Article
- Convergence of three parcellation approaches demonstrating cerebellar lobule volume deficits in Alcohol Use Disorder.NeuroImage. Clinical · 2019Article
- Sexually dimorphic structural abnormalities in major connections of the medial forebrain bundle in alcoholism.NeuroImage. Clinical · 2018Article
- Alcoholism Detection by Data Augmentation and Convolutional Neural Network with Stochastic Pooling.Journal of medical systems · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlcoholism has been linked to deficits in cognitive, behavioral, and emotional functions, and the cerebellum is important for optimal functioning of these abilities. However, little is known about how individual differences such as gender and drinking history might influence regional cerebellar abnormalities.
methodsVolumetric analyses of the cerebellum and its subregions were performed in relation to the interaction of gender and measures of drinking history. Structural magnetic resonance imaging scans of 44 alcoholic individuals (23 men) and 39 nonalcoholic controls (18 men) were obtained. In addition to measuring total cerebellar gray and white matter volumes, we measured 64 individual cerebellar parcellation units, as well as functionally defined a priori regions of interest that have been shown to correspond to functions impaired in alcoholism.
resultsTotal cerebellar white matter volume was smaller in alcoholic relative to nonalcoholic participants. Moreover, volumes of parcellation units varied with drinking history, showing negative associations between years of heavy drinking and the anterior lobe, the vestibulocerebellar lobe, and the spinocerebellar subdivision. The negative association between anterior volume and years of heavy drinking was driven primarily by alcoholic men. Additionally, we observed larger white and gray matter volumes for alcoholic women than for alcoholic men.
conclusionsThe identification of drinking-related abnormalities in cerebellar subregions lays a foundation that can be utilized to inform how cerebro-cerebellar networks are perturbed in this pathological condition. These results also provide estimates of how gender and individual differences in drinking history can predict cerebellar volumes.
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Registered trials
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