SynthesisIntegrative cancer therapies2016
Relationship Between Breast Density and Selective Estrogen-Receptor Modulators, Aromatase Inhibitors, Physical Activity, and Diet: A Systematic Review.
Synthesis in Integrative cancer therapies, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Dietary Patterns, Dietary Interventions, and Mammographic Breast Density: A Systematic Literature Review.Nutrients · 2022Pooled it
- Mammographic density, endocrine therapy and breast cancer risk: a prognostic and predictive biomarker review.The Cochrane database of systematic reviews · 2021Pooled it
- Sulindac, a Nonselective NSAID, Reduces Breast Density in Postmenopausal Women with Breast Cancer Treated with Aromatase Inhibitors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021Trial
- Adherence to the WCRF/AICR cancer prevention recommendations and mammographic density.Breast cancer research : BCR · 2026Article
- Mammographic Breast Density at Breast Cancer Diagnosis and Breast Cancer-Specific Survival.Diagnostics (Basel, Switzerland) · 2024Article
- WHO-recommended levels of physical activity in relation to mammographic breast density, mammographic tumor appearance, and mode of detection of breast cancer.Breast cancer research : BCR · 2024Article
- Physical Activity and Mammographic Density in Japanese Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Examining the Health-Related Needs of Females during Menopause: A Systematic Review Study.Journal of menopausal medicine · 2023Review
- Factors Influencing Mammographic Density in Asian Women: A Retrospective Cohort Study in the Northeast Region of Peninsular Malaysia.Diagnostics (Basel, Switzerland) · 2022Article
- Perception of Breast Density Information Among Women in Miami, FL: a Qualitative Study.Journal of cancer education : the official journal of the American Association for Cancer Education · 2022Article
- Sugar-sweetened beverage consumption and breast composition in a longitudinal study of Chilean girls.Breast cancer research : BCR · 2022Article
- Impact of hormonal therapy and other adjuvant therapies on contralateral breast volume change after implant-based breast reconstruction.Archives of plastic surgery · 2018Article
- Mammographic Density Distribution in Ras Al Khaimah (RAK): Relationships with Demographic and Reproductive FactorsAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Errors in Mammography Cannot be Solved Through Technology AloneAsian Pacific journal of cancer prevention : APJCP · 2018Review
- Qualitative Versus Quantitative Mammographic Breast Density Assessment: Applications for the US and Abroad.Diagnostics (Basel, Switzerland) · 2017Review
- Breast Cancer in Australian Indigenous Women: Incidence, Mortality, and Risk FactorsAsian Pacific journal of cancer prevention : APJCP · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Lower breast density (BD) is associated with lower risk of breast cancer and may serve as a biomarker for the efficacy of chemopreventive strategies. This review explores parameters that are thought to be associated with lower BD. We conducted a systematic review of articles published to date using the PRISMA strategy. Articles that assessed change in BD with estrogen-receptor modulators (tamoxifene [TAM], raloxifene [RLX], and tibolone) and aromatase inhibitors (AIs), as well as cross-sectional and longitudinal studies (LSs) that assessed association between BD and physical activity (PA) or diet were reviewed. Results Ten studies assessed change in BD with TAM; all reported TAM-mediated BD decreases. Change in BD with RLX was assessed by 11 studies; 3 reported a reduction in BD. Effect of tibolone was assessed by 5 RCTs; only 1 reported change in BD. AI-mediated BD reduction was reported by 3 out of 10 studies. The association between PA and BD was assessed by 21 studies; 4 reported an inverse association. The relationship between diet and BD was assessed in 34 studies. All studies on calcium and vitamin D as well as vegetable intake reported an inverse association with BD in premenopausal women. Two RCTs demonstrated BD reduction with a low-fat, high-carbohydrate intervention. Conclusion TAM induces BD reduction; however, the effect of RLX, tibolone, and AIs on BD is unclear. Although data on association between diet and BD in adulthood are contradictory, intake of vegetables, vitamin D, and calcium appear to be associated with lower BD in premenopausal women.
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