Evidence map›Paper›PMID 27130546›Full record

ReviewExperimental eye research2017

ATP sensitive potassium channel openers: A new class of ocular hypotensive agents.

Uttio Roy Chowdhury, Peter I Dosa, Michael P Fautsch

Open access · greenAbstract readReview
In one paragraph

Review in Experimental eye research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

  1. KThe Journal of pharmacology and experimental therapeutics · 2023
    Article
  2. Preclinical Pharmacokinetic Profile of Topical Ophthalmic and Intravenous Delivery of QLS-101, a Novel ATP-Sensitive Potassium Channel Opening Ocular Hypotensive Agent.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2023
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Pharmacological Profile and Ocular Hypotensive Effects of Cromakalim Prodrug 1, a Novel ATP-Sensitive Potassium Channel Opener, in Normotensive Dogs and Nonhuman Primates.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2021
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Novel Therapeutics in Glaucoma Management.Current neuropharmacology · 2018
    Review
  17. Article
  18. Article
  19. Differential Intraocular Pressure Measurements by Tonometry and Direct Cannulation After Treatment with Soluble Adenylyl Cyclase Inhibitors.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2017
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Uttio Roy ChowdhuryDept. of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. Electronic address: roychowdhury.uttio@mayo.edu.
Peter I DosaInstitute for Therapeutics Discovery and Development, Department of Medicinal Chemistry, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN 55414, United States. Electronic address: pidosa@umn.edu.
Michael P FautschDept. of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. Electronic address: fautsch.michael@mayo.edu.
Mayo Clinic · USUniversity of Minnesota · US

Funding

Intraocular pressure regulation via ATP-sensitive potassium channelsR01EY021727 · NEI · MAYO CLINIC ROCHESTER · PI FAUTSCH, MICHAEL P. · 2011 to 2021
$4.1M
NEI NIH HHS R01 EY021727
6 · The paper itself

Abstract

ATP sensitive potassium (K

Indexed as

AnimalsAntihypertensive AgentsCromakalimDiazoxideGlaucomaHumansIntraocular PressureKATP ChannelsNicorandilTrabecular MeshworkAntihypertensive AgentsCromakalimDiazoxideKATP ChannelsNicorandilATP sensitive potassium channel openersCromakalimDiazoxideGlaucomaIntraocular pressureNicorandilPotassium channel openersTrabecular meshwork

Identifiers

PMID27130546
PMCPMC5081279
OpenAlexW2345329626

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.