ArticleeLife2016
The role of piriform associative connections in odor categorization.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Brain-wide activity mapping reveals the somatosensory cortex as a sex-specific regulator of hedonic feeding.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- How the olfactory bulb maintains stable odor manifolds amid adaptation and representational drift.bioRxiv : the preprint server for biology · 2026Article
- Characterizing Olfactory Brain Responses in Young Infants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Olfactory testing in infants with perinatal asphyxia: Enhancing encephalopathy risk stratification for future health outcomes.Neuroscience and biobehavioral reviews · 2025Review
- Relationship of left piriform cortex network centrality with temporal lobe epilepsy duration and drug resistance.European journal of neurology · 2025Article
- The Impact of Odor Category Similarity on Multimedia Experience.Experimental neurobiology · 2024Article
- Connectivity of the Piriform Cortex and its Implications in Temporal Lobe Epilepsy.medRxiv : the preprint server for health sciences · 2024Article
- Semantic context-dependent neural representations of odors in the human piriform cortex revealed by 7T MRI.Human brain mapping · 2024Article
- High-precision mapping reveals the structure of odor coding in the human brain.Nature neuroscience · 2023Article
- A comparative neuroimaging perspective of olfaction and higher-order olfactory processing: on health and disease.Seminars in cell & developmental biology · 2022Review
- Mapping the Microstructure and Striae of the Human Olfactory Tract with Diffusion MRI.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Odor Canopy: A Method for Comfortable Odorant Delivery in MRI.Chemical senses · 2021Article
- Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities.Chemical senses · 2020Article
- Cell-Type-Specific Whole-Brain Direct Inputs to the Anterior and Posterior Piriform Cortex.Frontiers in neural circuits · 2020Article
- A Systematic Framework for Olfactory Bulb Signal Transformations.Frontiers in computational neuroscience · 2020Article
- Task-Demand-Dependent Neural Representation of Odor Information in the Olfactory Bulb and Posterior Piriform Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Repetition suppression: a means to index neural representations using BOLD?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Distributed neural activity patterns are widely proposed to underlie object identification and categorization in the brain. In the olfactory domain, pattern-based representations of odor objects are encoded in piriform cortex. This region receives both afferent and associative inputs, though their relative contributions to odor perception are poorly understood. Here, we combined a placebo-controlled pharmacological fMRI paradigm with multivariate pattern analyses to test the role of associative connections in sustaining olfactory categorical representations. Administration of baclofen, a GABA(B) agonist known to attenuate piriform associative inputs, interfered with within-category pattern separation in piriform cortex, and the magnitude of this drug-induced change predicted perceptual alterations in fine-odor discrimination performance. Comparatively, baclofen reduced pattern separation between odor categories in orbitofrontal cortex, and impeded within-category generalization in hippocampus. Our findings suggest that odor categorization is a dynamic process concurrently engaging stimulus discrimination and generalization at different stages of olfactory information processing, and highlight the importance of associative networks in maintaining categorical boundaries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.