Trial reportBMJ open2016
Validating the use of Hospital Episode Statistics data and comparison of costing methodologies for economic evaluation: an end-of-life case study from the Cluster randomised triAl of PSA testing for Prostate cancer (CAP).
Trial report in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Impact of PSA testing on secondary care costs in England and Wales: estimates from the Cluster randomised triAl of PSA testing for Prostate cancer (CAP).BMC health services research · 2023Trial
- Long-term costs associated with healthcare use of people with cancer in Scotland.The European journal of health economics : HEPAC : health economics in prevention and care · 2026Article
- Cost Utility of Specialist Physiotherapy for Functional Motor Disorder (Physio4FMD): Economic Analysis of a Pragmatic Randomized Controlled Trial.Neurology. Clinical practice · 2025Article
- Does the cost of cancer care for people in prison differ from those in the general population? Analysis of matched English cancer registry and hospital records.EClinicalMedicine · 2024Article
- Local Instrumental Variable Methods to Address Confounding and Heterogeneity when Using Electronic Health Records: An Application to Emergency Surgery.Medical decision making : an international journal of the Society for Medical Decision Making · 2022Article
- Uptake and outcomes of robotic gynaecological surgery in England (2006-2018): an account of Hospital Episodes Statistics (HES).Journal of robotic surgery · 2022Article
- Assessing long-term survival and hospitalization following transvenous lead extraction in patients with cardiac resynchronization therapy devices: A propensity score-matched analysis.Heart rhythm O2 · 2021Article
- A retrospective cohort study comparing clinical outcomes and healthcare resource utilisation in patients undergoing surgery for osteomyelitis in England: a case for reorganising orthopaedic infection services.Journal of bone and joint infection · 2021Article
- Unexpected tunnelled central venous access demise: a single institutional study from the UK.Pediatric surgery international · 2021Article
- Polygenic risk-tailored screening for prostate cancer: A benefit-harm and cost-effectiveness modelling study.PLoS medicine · 2019Article
- Geographical disparities in treatment and health care costs for end-of-life cancer patients in China: a retrospective study.BMC cancer · 2019Article
- The Impact of Hospital Costing Methods on Cost-Effectiveness Analysis: A Case Study.PharmacoEconomics · 2018Article
- Article
- Retrospective analysis of the national impact of industrial action by English junior doctors in 2016.BMJ open · 2018Article
- A methodological framework for assessing agreement between cost-effectiveness outcomes estimated using alternative sources of data on treatment costs and effects for trial-based economic evaluations.The European journal of health economics : HEPAC : health economics in prevention and care · 2018Article
- Economic Evaluations Alongside Efficient Study Designs Using Large Observational Datasets: the PLEASANT Trial Case Study.PharmacoEconomics · 2017Article
- Impact of laparoscopic versus open surgery on hospital costs for colon cancer: a population-based retrospective cohort study.BMJ open · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
objectivesTo evaluate the accuracy of routine data for costing inpatient resource use in a large clinical trial and to investigate costing methodologies.
designFinal-year inpatient cost profiles were derived using (1) data extracted from medical records mapped to the National Health Service (NHS) reference costs via service codes and (2) Hospital Episode Statistics (HES) data using NHS reference costs. Trust finance departments were consulted to obtain costs for comparison purposes.
setting7 UK secondary care centres. POPULATION: A subsample of 292 men identified as having died at least a year after being diagnosed with prostate cancer in Cluster randomised triAl of PSA testing for Prostate cancer (CAP), a long-running trial to evaluate the effectiveness and cost-effectiveness of prostate-specific antigen (PSA) testing.
resultsBoth inpatient cost profiles showed a rise in costs in the months leading up to death, and were broadly similar. The difference in mean inpatient costs was £899, with HES data yielding ∼8% lower costs than medical record data (differences compatible with chance, p=0.3). Events were missing from both data sets. 11 men (3.8%) had events identified in HES that were all missing from medical record review, while 7 men (2.4%) had events identified in medical record review that were all missing from HES. The response from finance departments to requests for cost data was poor: only 3 of 7 departments returned adequate data sets within 6 months.
conclusionsUsing HES routine data coupled with NHS reference costs resulted in mean annual inpatient costs that were very similar to those derived via medical record review; therefore, routinely available data can be used as the primary method of costing resource use in large clinical trials. Neither HES nor medical record review represent gold standards of data collection. Requesting cost data from finance departments is impractical for large clinical trials. TRIAL REGISTRATION NUMBER: ISRCTN92187251; Pre-results.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.